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Cage subsidence—A multifactorial matter!
Study designRetrospective cohort study
ObjectiveWider cages are associated with improved decompression and reduced subsidence, but variation in cage...
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Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool
BackgroundIt is now understood that it is the quality rather than the absolute amount of adipose tissue that confers risk for obesity-associated...
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Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles
IntroductionThe transition to metabolically unhealthy obesity (MUO) is driven by the limited expandability of adipose tissue (AT). Familial Partial...
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A higher proportion of small adipocytes is associated with increased visceral and ectopic lipid accumulation during weight gain in response to overfeeding in men
BackgroundAdipose tissue (AT) expansion occurs by hypertrophy (increase in size) and hyperplasia (increase in number) of adipocytes. The AT...
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Expansion of India’s national child healthcare programme, Rashtriya Bal Swasthya Karyakram (RBSK), for rare disease management : a health policy perspective
Rare diseases (RD) are severe and debilitating conditions. They are one of the leading causes of childhood mortality globally. In India, RDs have not...
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A comparative analysis of lung function and spirometry parameters in genotype-controlled natives living at low and high altitude
BackgroundThe reference values for lung function are associated to anatomical and lung morphology parameters, but anthropometry it is not the only...
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Use of machine learning to identify patients at risk of sub-optimal adherence: study based on real-world data from 10,929 children using a connected auto-injector device
BackgroundOur aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early...
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Weight gain trajectories patterns from pregnancy to early postpartum: identifying women at risk and timing to prevent weight regain
BackgroundWoman's weight changes during pregnancy and postpartum contribute to obesity and health outcomes later in life. This study aimed to...
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Adipogenic progenitors in different organs: Pathophysiological implications
In physiological conditions, the adipose organ resides in well-defined areas, where it acts providing an energy supply and as an endocrine organ...
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Alteration of BDNF, SPARC, FGF-21, and GDF-15 circulating levels after 1 year of anti-obesity treatments and their association with 1-year weight loss
PurposeEmerging evidence revealed that brain-derived neurotrophic factor (BDNF), secreted protein acidic and rich in cysteine (SPARC), fibroblast...
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Comparative effectiveness of smartphone healthcare applications for improving quality of life in lung cancer patients: study protocol
BackgroundAlthough pulmonary rehabilitation is helpful for patients following lung cancer surgery, rehabilitation is not widely available, due in...
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Serial change in gastric motility in eosinophilic gastritis with pyloric stenosis assessment by abdominal ultrasonography
Eosinophilic gastritis (EoG) is defined as the presence of upper gastrointestinal symptoms combined with histologic findings of > 30...
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Transplantation of Human Embryonic Stem Cell–Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia
Critical limb ischemia (CLI) is a state of severe peripheral artery disease, with no effective treatment. Cell therapy has been investigated as a...
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Successful removal of an iatrogenic pleural foreign body—pigtail catheter, using a semi-rigid thoracoscope
Tube thoracostomy stands as the conventional treatment for pleural diseases. Nevertheless, pigtail catheters have gained traction due to their...
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NAFLD as a continuum: from obesity to metabolic syndrome and diabetes
BackgroundThe prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly. It is nowadays recognized as the most frequent...
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Obesity and the risk of cardiometabolic diseases
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as...
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Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
Obesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight...
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Do patients with Prader–Willi syndrome have favorable glucose metabolism?
BackgroundIn recent years, more studies have observed that patients with Prader–Willi syndrome have lower insulin levels and lower insulin resistance...
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Medium-Term Outcomes of Stent Therapy for Aortic Coarctation in Children Under 30 kg with New Generation Low-Profile Stents: A Follow-Up Study of a Single Centre Experience
We previously reported short-term outcomes for stenting of aortic coarctation (CoA) (native or re-coarctation) with newer generation low-profile...
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Malignant pleural effusion: current understanding and therapeutic approach
Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality and...
