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A Cholecystokinin Analogue Ameliorates Cognitive Deficits and Regulates Mitochondrial Dynamics via the AMPK/Drp1 Pathway in APP/PS1 Mice
BackgroundThere are no drugs on the market that can reverse or slow Alzheimer’s disease (AD) progression. A protease-resistant Cholecystokinin (CCK)...
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Banxia **exin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice
ObjectiveTo identify whether Banxia **exin Decoction (BXD) alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in...
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VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration
Activation of innate immunity in the brain is a prominent feature of Alzheimer’s disease (AD). The present study investigated the regulation of...
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Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer’s disease
Although there are indications of a trend towards less severe acute respiratory symptoms and a decline in overall lethality from the novel...
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[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice
BackgroundOxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD)....
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NREM sleep loss increases neurofilament light chain levels in APP/PS1 and C57BL/6 J mice
PurposeSleep disturbances exacerbate the progression of Alzheimer’s disease (AD), but disturbances of non-rapid eye movement (NREM) sleep and rapid...
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Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice
Cognitive impairment is the main clinical manifestation of Alzheimer’s disease (AD), and amyloid-β (Aβ) deposition and senile plaques are the...
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Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
BackgroundAlzheimer’s disease (AD) is the most common dementia worldwide, and there is still no satisfactory drug or therapeutic strategy. Polygala...
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Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Current drugs...
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Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice
BackgroundSuan-Zao-Ren Decoction (SZRD) has been widely used to treat neurological illnesses, including dementia, insomnia and depression. However,...
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ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease (AD), although neither precise etiology nor...
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Chronic intermittent hypoxia induces cognitive impairment in Alzheimer’s disease mouse model via postsynaptic mechanisms
PurposeObstructive sleep apnea (OSA) is highly comorbid with Alzheimer’s disease (AD) and may represent a risk factor for inducing or accelerating...
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Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice
Alzheimer’s disease (AD) shows cognitive impairments in clinic, which is multifactorial with different etiopathogenic mechanisms such as Aβ...
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Kai-**n-San protects against mitochondrial dysfunction in Alzheimer’s disease through SIRT3/NLRP3 pathway
BackgroundKai-**n-San (KXS) has been reported to have a good curative impact on dementia. The purpose of the study was to determine whether KXS might...
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Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the...
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Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease
Early onset familial Alzheimer’s disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are...
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Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
BackgroundP2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [ 11 C]SMW139...
