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Association Between Total Genotype Score and Muscle Injuries in Top-Level Football Players: a Pilot Study
BackgroundRecently, genetic predisposition to injury has become a popular area of research and the association between a few single nucleotide...
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Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training
BackgroundMuscle weakness and decreased fatigue resistance are key manifestations of systemic autoimmune myopathies (SAMs). We here examined whether...
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Bridging Health Disparities: a Genomics and Transcriptomics Analysis by Race in Prostate Cancer
As the era of cancer genomics expands, disproportionate rates of prostate cancer incidence and mortality by race have demonstrated increasing...
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Origin and Evolution of RAS Membrane Targeting
KRAS , HRAS and NRAS proto-oncogenes belong to a family of 40 highly homologous genes, which in turn are a subset of a superfamily of >160 genes...
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The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome
Down syndrome (DS) stands as the prevalent genetic cause of intellectual disability, yet comprehensive understanding of its cellular and molecular...
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Identification of gene expression biomarkers to predict clinical response to methotrexate in patients with rheumatoid arthritis
ObjectivesTo identify biomarkers at the gene expression level to predict response to methotrexate (MTX) in patients with rheumatoid arthritis (RA).
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The prevalence of ADSL (rs3788579) and CYP1A2 (rs17861162) polymorphisms in female breast cancer patients in North-West Iran
IntroductionBreast cancer is a prevalent and significant contributor to cancer-related mortality among women worldwide. Its increasing incidence,...
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Clinical exome sequencing elucidates underlying cause of death in sudden unexpected death of infants: two case reports
Sudden unexpected death in infants (SUDI) is a traumatic event for families, and unfortunately its occurrence remains high in many parts of the...
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Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a...
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Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis
BackgroundThe meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and...
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Screening and validation of plasma cell-derived, purinergic, and calcium signalling-related genetic signature to predict prognosis and PD-L1/PD-1 blockade responses in lung adenocarcinoma
BackgroundThis study aims at screening and validation of prospective genetic signature for lung adenocarcinoma (LUAD) prognosis and treatment.
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Diagnostic yield of multi-gene panel for muscular dystrophies and other hereditary myopathies
Genetic testing is being considered the first-step in the investigation of hereditary myopathies. However, the performance of the different testing...
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EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells
Tyrosine kinase inhibitors (TKIs) are highly effective in treating chronic myelogenous leukemia (CML). However, primary and acquired drug resistance...
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Alterations in the balance of sex hormones may affect rat prostatic inflammation and fibrosis, and osteopontin might be involved in this process
ObjectiveThis study aimed to investigate the effects of sex hormone imbalance on rat prostatic inflammation and fibrosis and identify the key...
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Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma
Mutations in IDH1/2 and the epigenetic silencing of TET2 occur in leukaemia or glioma in a mutually exclusive manner. Although intrahepatic...
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Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease
Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical...
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Muskelschwäche und CK‑Erhöhung: Ist es immer eine Myositis?
Rheumatologists are often confronted by patients with muscle weakness and elevated creatine kinase (CK) levels. Myositis cannot always be determined...
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Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia
Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder...
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Creation and implementation of a European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC registry)
BackgroundInternational patient registries are of particular importance for rare disorders, as they may contribute to overcome the lack of knowledge...
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Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
ObjectiveTo investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular...
