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Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression
AML with chromosomal alterations involving 3q26 overexpresses the transcription factor (TF) EVI1, associated with therapy refractoriness and inferior...
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A new case of trisomy 5 with complex karyotype abnormalities in B-cell prolymphocytic leukemia: a case study
BackgroundThe B-cell prolymphocytic leukemia (B-PLL) diagnosis is challenging due to the superposition with mature B-cell leukemia and/or lymphoma.
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Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia
Deregulation of the EVI1 proto-oncogene by the GATA2 distal hematopoietic enhancer ( G2DHE ) is a key event in high-risk acute myeloid leukemia...
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Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective
RUNX1 is a critical transcription factor for the emergence of definitive hematopoiesis and the precise regulation of adult hematopoiesis....
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Significance of Somatic Mutation Profiling in CML Beyond BCR-ABL: A Retrospective Study of the Indian Population
Somatic mutation and fusion detection in acute myeloid leukemia to determine disease subtype and treatment regime is a common practice, but it’s not...
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Molecular analysis of more than 140 gene fusion variants and aberrant activation of EVI1 and TLX1 in hematological malignancies
Gene fusions are observed in abnormal chromosomal rearrangements such as translocations in hematopoietic malignancies, especially leukemia subtypes....
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Detection of 22 common leukemic fusion genes using a single-step multiplex qRT-PCR-based assay
BackgroundFusion genes generated from chromosomal translocation play an important role in hematological malignancies. Detection of fusion genes...
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PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias
It has been shown that individual acute myeloid leukemia (AML) patients are characterized by one of few initiating DNA mutations and 5–10 cooperating...
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FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice
Osteoblasts, the bone forming cells, affect self-renewal and expansion of hematopoietic stem cells (HSCs), as well as homing of healthy hematopoietic...
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−7/7q− syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity
The recurrence of chromosomal abnormalities in a specific subtype of cancer strongly suggests that dysregulated gene expression in the corresponding...
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Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription
The EVI1 gene (3q26) codes for a transcription factor with important roles in normal hematopoiesis and leukemogenesis. High expression of EVI1 is a...
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Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway
Animal models are established tools to study basic questions of biology in a systematic way. They have greatly facilitated our understanding of the...
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Comprehensive array CGH of normal karyotype myelodysplastic syndromes reveals hidden recurrent and individual genomic copy number alterations with prognostic relevance
About 40% of patients with myelodysplastic syndromes (MDSs) present with a normal karyotype, and they are facing different courses of disease. To...
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CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility
CYP2B6 is a highly variable and polymorphic cytochrome P450 enzyme which plays a vital role in the degradation of some endogenous metabolites,...
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Genetic alterations in children and adolescents with acute myeloid leukaemia
Acute Myeloid Leukemia is a clinically and genetically heterogeneous disease, in which cytogenetic aberrations are the most important factors to...
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Evi-1 as a critical regulator of leukemic cells
Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia....
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