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Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging
ObjectiveThe performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to...
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Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro‐computed tomography and positron emission tomography study in rabbits
AimThe purpose of this study was to evaluate using microCT and positron emission tomography (PET) analysis, the influence on bone healing of the...
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Technical opportunities and challenges in develo** total-body PET scanners for mice and rats
Positron emission tomography (PET) is the most sensitive in vivo molecular imaging technique available. Small animal PET has been widely used in...
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Positron Emission Tomographic Imaging of Tumor Cell Death Using Zirconium-89-Labeled APOMAB® Following Cisplatin Chemotherapy in Lung and Ovarian Cancer Xenograft Models
PurposeEarly detection of tumor treatment responses represents an unmet clinical need with no approved noninvasive methods. DAB4, or its chimeric...
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PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine
PurposeMetabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission...
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Accuracy and Precision of Iodine Quantification in Subtracted Micro-Computed Tomography: Effect of Reconstruction and Noise Removal Algorithms
PurposeTo evaluate the effect of reconstruction and noise removal algorithms on the accuracy and precision of iodine concentration (C I ) quantified...
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Preclinical evaluation of [18F]SYN1 and [18F]SYN2, novel radiotracers for PET myocardial perfusion imaging
BackgroundPositron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery...
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Evaluating tissue-engineered repair material for pelvic floor dysfunction: a comparison of in vivo response to meshes implanted in rats
Introduction and hypothesisAchieving better anatomic restoration and decreasing the associated complications are necessary for material repair of...
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EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer
PurposeExtradomain B of fibronectin (EDB-FN) is a promising diagnostic and therapeutic biomarker for thyroid cancer (TC). Here, we identified a...
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Detection and therapy of neuroblastoma minimal residual disease using [64/67Cu]Cu-SARTATE in a preclinical model of hepatic metastases
BackgroundA major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal...
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68Ga-labelled desferrioxamine-B for bacterial infection imaging
PurposeWith the increase of especially hospital-acquired infections, timely and accurate diagnosis of bacterial infections is crucial for effective...
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Evaluation of image quality with four positron emitters and three preclinical PET/CT systems
BackgroundWe investigated the image quality of 11 C, 68 Ga, 18 F and 89 Zr, which have different positron fractions, physical half-lifes and positron...
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Detection of Osteoarthritis Inflammation by Single-Photon Emission Computed Tomography Based on an Inflammation-Targeting Peptide cFLFLF
PurposeAlthough inflammation has been recognized as a key process in the pathogenesis of osteoarthritis (OA), there remains no clinical noninvasive...
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Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy
BackgroundSurgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours...
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Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats
PurposePreclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In...
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Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®
PurposeThe chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antigen, which is...
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177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma
PurposeTEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and...
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Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection
PurposeAspergillus fumigatus produces the siderophore triacetylfusarinine C (TAFC) for iron acquisition which is essential for its virulence....
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Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis
BackgroundWe recently reported that enhanced [18F]-fluorodeoxyglucose (FDG) uptake in skeletal muscles predicts disease aggressiveness in patients...
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Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution
BackgroundMesenchymal stem cells (MSCs) have shown potential for treatment of different diseases. However, their working mechanism is still unknown....
