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Protein kinase C delta mediates Pasireotide effects in an ACTH-secreting pituitary tumor cell line
PurposeClinical control of corticotroph tumors is difficult to achieve since they usually persist or relapse after surgery. Pasireotide is approved...
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ACTH vs steroids for the treatment of acute gout in hospitalized patients: a randomized, open label, comparative study
The management of acute gout in the hospital setting may be challenging since most patients are elderly with multiple unstable comorbidities....
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Diagnostic accuracy of bilateral inferior petrosal sinus sampling using desmopressin or corticotropic- releasing hormone in ACTH-dependent Cushing’s syndrome: A systematic review and meta-analysis
The current gold standard diagnostic method for Cushing disease (CD) is bilateral inferior petrosal sinus sampling (BIPSS) after...
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The diagnostic yield of inferior petrosal sinus sampling in Cushing syndrome in the era of ovine CRH shortage
PurposeThe ovine corticotropin-releasing hormone (oCRH) stimulation test has been routinely used in the diagnostic work-up of ACTH-dependent Cushing...
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Adrenocortical suppression in children with nephrotic syndrome treated with corticosteroids
BackgroundChildren with nephrotic syndrome are exposed to alternate day steroids for prolonged periods and this poses the need for evaluation of...
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Comparison of the preoperative diagnostic accuracy of BIPSS versus MRI for Cushing disease: a single-centre experience
BackgroundCushing disease (CD) arises due to a pituitary corticotroph adenoma, which is the most common cause of Cushing syndrome (CS). Bilateral...
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A rare case of pancreatic neuroendocrine neoplasm causing Cushing’s syndrome
Pancreatic neuroendocrine neoplasms (PNENs) are relatively rare with a reported incidence of 1–2/100,000 and generally thought to originate from the...
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Adrenal function/dysfunction in critically ill patients: a concise narrative review of recent novel insights
The “fight or flight” response to critical illness relies on increased cortisol availability, traditionally attributed to several-fold-increased...
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The value of [68Ga]Ga-DOTA-TATE PET/CT in diagnosis and management of suspected pituitary tumors
BackgroundGallium 68-tetraazacyclododecane-tetraacetic acid-octreotate ([68Ga]Ga-DOTA-TATE) is a selective somatostatin analogue ligand, which shows...
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Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis
PurposeThe clinical and hormonal overlap between neoplastic (CS) and non-neoplastic (NNH/pCS) hypercortisolism is a challenge. Various dynamic tests...
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Erratum: Association of Child Neurology (AOCN) — Indian Epilepsy Society (IES) Consensus Guidelines for the Diagnosis and Management of West Syndrome
The first sentence of last paragraph, column 1, page 61 should read: “In the 2004 United Kingdom Infantile Spasms study, spasm freedom was achieved...
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Daoyin therapy in chronic neck pain: study protocol for a randomized controlled trial
BackgroundDaoyin therapy (DT), an ancient therapeutic approach with a history spanning thousands of years, has traditionally been employed to address...
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Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing’s disease
PurposePituitary apoplexy is a rare endocrine emergency. The purpose of this study is to characterize physiological changes involved in pituitary...
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Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases
Pituitary adenomas are rare in children and young people under the age of 19 (hereafter referred to as CYP) but they pose some different diagnostic...
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Management of Central Diabetes Insipidus in Disabled Children with Diluted Oral Desmopressin Lyophilisate Formulation Administered Through Nasogastric Tube: A Retrospective Case Series
BackgroundExperience with nasogastric administration of oral DDAVP [desamino- d -arginine-8-vasopressin] lyophilisate (ODL) for central diabetes...
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Cushing’s disease: adrenal steroidogenesis inhibitors
Cushing’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome...
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Hypothalamic-Pituitary-Adrenal Axis Responses in Women with Endometriosis-Related Chronic Pelvic Pain
Some chronic pain conditions and comorbidities suppress the hypothalamic-pituitary-adrenal (HPA) axis and response to dynamic testing. We measured...
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Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial
BackgroundThis study aimed to compare the effects of melatonin, dexmedetomidine, and gabapentin on postoperative pain and anxiety following...
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The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study
BackgroundVasopressin is a second-line vasoactive agent for refractory septic shock. Vasopressin loading is not generally performed because of the...
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Clinical and therapeutic outcomes of pediatric pituitary adenomas: a single pituitary center experience
PurposePediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be challenging to manage. Most studies evaluating PPA...