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Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease
PurposeAltered serotonergic neurotransmission may contribute to the non-motor features commonly associated with Parkinson’s disease (PD) such as...
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Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept
5-hydroxytryptophan (5-HTP) has shown therapeutic promise in a range of human CNS disorders. But native 5-HTP immediate release (IR) is poorly...
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Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder
Alterations in tryptophan and serotonin have been implicated in various mental disorders; but studies are limited on child neurodevelopmental...
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Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors
Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain....
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The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
BackgroundSerotonin receptors 5-HT1B and 5-HT1D in the cerebral arteries are activated by the 5-hydroxytryptophan agonists (triptans) to relieve the...
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Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression
BackgroundThe pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut...
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Late-onset symptomatic hyperprolactinemia in 6-pyruvoyl-tetrahydropterin synthase deficiency
BackgroundTetrahydrobiopterin (BH 4 ) deficiency caused by 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is a rare disorder that is one of...
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The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review
Serotonin or 5-hydroxytryptamine (5-HT)- a neurotransmitter of both the Enteric Nervous System and the Central Nervous System is synthesized by the...
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The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque
Psychiatric disorders, particularly depression and anxiety, are often associated with impaired serotonergic function. However, serotonergic...
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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
AbstractDespite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of great importance for...
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Tryptophan and serotonin levels as potent biomarkers in diabetes mellitus complications: a new approach of diagnostic role
ObjectiveAlterations in the serotonergic system were verified to act a role in the pathogenesis of altered neurological and psychiatric diseases. In...
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Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment
Impairment of insulin action and metabolic dysregulation have traditionally been associated with schizophrenia, although the molecular basis of such...
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Fluoxetine Ameliorates the Aggravation of UC Symptoms in C57BL/6 Mice Induced by CUMS
ObjectivePatients with chronic ulcerative colitis (UC) often have mental symptoms such as depression and anxiety, and stress can lead to...
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New Paradigm in the Management of REM Sleep Behavior Disorder
Purpose of ReviewRapid eye movement (REM) behavior disorder (RBD) is a complex parasomnia, with growing evidence showing that it represents a...
