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Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface
BackgroundChronic obstructive pulmonary disease (COPD) has the highest increased risk due to household air pollution arising from biomass fuel...
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DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is highly prevailing in Asia and it is ranked in the most aggressive squamous cell carcinomas....
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n-Hexane intoxication in a Chinese medicine pharmaceutical plant: a case report
Backgroundn -Hexane is a well-known neurotoxicant. Polyneuropathy due to occupational n -hexane exposure has been reported worldwide, however, our...
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Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging
PurposePositron emission tomography (PET) ligands targeting translocator protein (TSPO) are potential imaging diagnostics of cancer. In this study,...
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The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone
Spermatogenesis is contingent upon hormones and growth factors acting through endocrine and paracrine pathways either in vivo or in vitro . Sertoli...
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Detection of decomposition volatile organic compounds in soil following removal of remains from a surface deposition site
PurposeCadaver-detection dogs use volatile organic compounds (VOCs) to search for human remains including those deposited on or beneath soil. Soil...
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Flavoring exposure in food manufacturing
Flavorings are substances that alter or enhance the taste of food. Workers in the food-manufacturing industry, where flavorings are added to many...
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Urinary 2,5-hexanedione excretion in cryptogenic polyneuropathy compared to the general Swedish population
Background2,5-hexanedione (2,5-HD) is the main neurotoxic metabolite of methyl-n-butyl ketone (MBK) and n-hexane, and known to cause polyneuropathy....
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Volatile Substance Misuse: An Updated Review of Toxicity and Treatment
Educational campaigns and legislative actions may have led to an overall decrease in the prevalence of volatile substance misuse (VSM) in many...
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Clinical and forensic examinations of glycaemic marker methylglyoxal by means of high performance liquid chromatography–tandem mass spectrometry
The postmortem determination of hyperglycaemic coma is quite difficult because of the lack of morphological findings and the difficult interpretation...
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Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr cp /NDmcr rat kidney
BackgroundReactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction...
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Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats
BackgroundDoxorubicin is a potent chemotherapeutic drug used against a variety of cancers. It acts through interaction with polymerases and...
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A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company
Objectivesto assess environmental and biological monitoring of exposure to organic solvents in a glue-manufacturing company in Sfax, Tunisia.
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Testicular morphology and antispermatogenic effects of 2,4-dichlorophenoxyacetic acid (2,4-D) in male West African Dwarf (WAD) goats
This study investigated the testicular morphology as well as the gonadal and extra-gonadal sperm reserves of West African Dwarf (WAD) goats exposed...
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The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice
Lead is a ubiquitous environmental and industrial pollutant that may have toxic effects on the male. Vitamins may protect against toxic effects of...
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Re-establishment of spermatogenesis by diethylstilbestrol after 2,5-hexanedione-induced irreversible testicular atrophy in rats
To investigate the effects of diethylstilbestrol (DES) in reestablishing spermatogenesis and the mechanism by which estrogen works on...
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Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: Insight from animal studies
In this short review we provide evidence that the branched-chain keto acids accumulating in the neurometabolic disorder maple syrup urine disease...
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Monocyclic and dicyclic hydrocarbons: structural requirements for proximal giant axonopathy
The chromogenic and neurotoxic γ-diketone 1,2–diacetylbenzene (1,2-DAB), but not its isomer 1,3-DAB, induces blue discoloration of tissues and urine,...
