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High keratin 15 expression reflects favorable prognosis in early cervical cancer patients
ObjectiveKeratin 15 (KRT15) exhibits inconsistent prognostic roles in different cancers, and its prognostic value in early cervical cancer patients...
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Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection
BackgroundPolo-like kinase 4 (PLK4) serves as a marker for tumor features and poor outcomes in cancers. This study aimed to explore the associations...
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High-risk HPV-related squamous cell carcinoma in the temporal bone: a rare but noteworthy subtype
High-risk human papillomavirus (HPV) is a risk factor for the development of several head and neck squamous cell carcinomas (SCCs). However, there...
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Impact of formalin fixation on mismatch repair protein evaluation by immunohistochemistry
Mismatch repair/microsatellite instability (MMR/MSI) status in colorectal cancer (CRC) has become fundamental as a diagnostic, prognostic, and...
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Evaluation of Safe Margins Using Immunohistochemistry in Oral Squamous Cell Carcinoma
BackgroundHematoxylin & Eosin (H & E) stains have been conventionally used to establish the status of safe margins following resection of primary...
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Comparison of HercepTest™ mAb pharmDx (Dako Omnis, GE001) with Ventana PATHWAY anti-HER-2/neu (4B5) in breast cancer: correlation with HER2 amplification and HER2 low status
Performance of the new CE-IVD-marked HercepTest™ mAb pharmDx (Dako Omnis) assay (HercepTest (mAb)) was compared against the PATHWAY® anti-HER-2/neu...
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Frequent upregulation of HER2 protein in hormone-receptor-positive HER2-negative breast cancer after short-term neoadjuvant endocrine therapy
BackgroundEndocrine resistant metastatic disease develops in ~ 20–25% of hormone-receptor-positive (HR+) breast cancer (BC) patients despite...
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Anaplastic lymphoma kinase expression in PDGFRA-mutated gastrointestinal stromal tumors probably correlates with poor prognosis
BackgroundAnaplastic lymphoma kinase (ALK) overexpression and gene alterations have been detected in several mesenchymal tumors, with significant...
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Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
PurposeTo correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with...
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Imaging characteristics and neurosurgical outcome in subjects with agenesis of the corpus callosum and interhemispheric cysts
PurposeTo explore the relationships between clinical-radiological features and surgical outcomes in subjects with interhemispheric cysts (IHC) and...
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Contemporary evaluation of estrogen receptor and progesterone receptor expression in breast cancer-associated stroma
PurposeTo investigate nuclear estrogen receptor α (ERα) and progesterone receptor (PR) immunohistochemistry (IHC) patterns in the stroma surrounding...
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P53 Overexpression May Represent an Early Marker of Clinicopathologic Progression in Vasculogenic Mesenchymal Lesions of Germ Cell Tumor Origin
Vasculogenic mesenchymal lesions (VMLs) of germ cell tumor origin are thought to originate in postpubertal-type yolk sac tumor components and include...
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Spatial expression of claudin 18.2 in matched primaries and metastases of tubo-ovarian carcinoma of all subtypes
Physiologically, claudin 18 splice variant 2 (CLDN18.2) expression is restricted to the gastric epithelium, but its expression has been detected in...
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Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum
Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case...
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Co-existing Neuroendocrine Tumors in the Ileum and Pancreas: A Clinico-Pathological Challenge
Ileal (I) and pancreatic (Pan) neuroendocrine tumors (NETs) are among the most common digestive neuroendocrine neoplasms (NENs). Coexisting NETs at...
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Clinicopathological characteristics of gastric adenocarcinoma with enteroblastic differentiation and gastric adenocarcinoma with enteroblastic marker expression
Gastric adenocarcinoma (GA) with enteroblastic differentiation (GAED) is an aggressive carcinoma histologically characterized by a glycogen-rich...
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Effect of Selective Carboplatin-Induced Inner Hair Cell Loss on Temporal Integration in Chinchillas
Integration of acoustic information over time is essential for processing complex stimuli, such as speech, due to its continuous variability along...
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Clinicopathological characteristics of Non-Small Cell Lung Cancer (NSCLC) patients with c-MET exon 14 skip** mutation, MET overexpression and amplification
PurposeMET exon 14 skip** is one of the rare mutations in non-small cell lung cancer (NSCLC), involving its pathogenesis and progression. The...
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Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary – a review
BackgroundGranulosa cell tumors (GCT) are rare malignant ovarian tumors. The two subtypes, adult and juvenile granulosa cell tumors, differ in...
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Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study
BackgroundHuman papillomavirus (HPV) has been detected in eyelid sebaceous gland carcinoma (SGC) and squamous cell carcinoma (SCC), and detection...
