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Exercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Production
PurposeLong-term administration of glucocorticoids (GCs) increases myocardial oxidative stress. 4-Hydroxynonenal (4-HNE) protein adducts, a marker of...
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Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head
BackgroundOsteonecrosis of the femoral head (ONFH) is becoming a prevalent global health problem. 4-Hydroxynonenal (4-HNE) serves as a common marker...
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Aqueous humor and serum levels of 4-hydroxynonenal and 8-hydroxy-2′deoxyguanosine in pseudoexfoliation syndrome and glaucoma
PurposeTo compare the aqueous humor (AH) and serum levels of 4-hydroxynenal (4-HNE) and 8-hydroxy-2′-deoxyguanosine (8-OhdG) in patients with...
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Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells
PurposeOxidative stress is widely known to be a major contributor in the pathogenesis of dry eye disease (DED). 4-Hydroxynonenal (4-HNE), a...
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A New Aspect of Penehyclidine Hydrochloride in Alleviating Myocardial Ischemia–Reperfusion Injury: Ferroptosis
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with cardioprotective effects. Ferroptosis is closely related to myocardial...
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Metabolite signature in acute ischemic stroke thrombi: a systematic review
Metabolites are reliable biomarkers for many diseases. However, their role in acute ischemic stroke (AIS) pathogenesis is not well understood. In...
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Untargeted Metabolomic Analysis in Endolymphatic Sac Luminal Fluid from Patients with Meniere’s Disease
Dysfunction of the endolymphatic sac (ES) is one of the etiologies of Meniere’s disease (MD), the mechanism of which remains unclear. The aim of the...
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Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice
AimAcute pancreatitis is a common and potentially serious condition. However, a specific treatment for this condition is still lacking. Genistein,...
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Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: evaluation of oxidative stress and inflammatory markers
PurposePapillary thyroid carcinoma (PTC) is the most frequent subtype of thyroid cancer; Hashimoto's thyroiditis (HT), autoimmune disease, commonly...
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Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db/db mice
BackgroundType 2 diabetes mellitus (T2DM), a growing health problem worldwide, is a metabolic disorder characterized by hyperglycemia due to insulin...
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Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery
BackgroundTissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or...
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The Effects of Systemic Use of Epigallocatechin Gallate in Thermal Injury Progression
The burn wound progression is a complex process caused by inadequate tissue perfusion, free radical damage, and altered cytokine levels in burn...
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Whey proteins inhibit food intake and tend to improve oxidative balance in obese zucker rats
Background/AimsWhey proteins (WP), obtained from milk after casein precipitation, represent a heterogeneous group of proteins. WP are reported to...
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Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR
Hypercholesterolemia is a major risk factor for coronary artery diseases and cardiac ischemic events. Cholesterol per se could also have negative...
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Do different lipid components accelerate the pathogenesis and severity of Diabetic Retinopathy?
BackgroundTo assess the association of lipid and lipid-derived toxic molecules in pathogenesis and severity of diabetic retinopathy (DR) in type 2...
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Endogenous toxic metabolites and implications in cancer therapy
It is well recognized that many metabolic enzymes play essential roles in cancer cells in producing building blocks such as nucleotides, which are...
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Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model
Tropospheric ozone (O 3 ) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O 3 -mediated...
