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Identification of key genes and immune infiltration in osteoarthritis through analysis of zinc metabolism-related genes
BackgroundOsteoarthritis (OA) represents a prominent etiology of considerable pain and disability, and conventional imaging methods lack sensitivity...
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Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation
BackgroundExploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we aimed to...
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Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational...
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Spatiotemporal expression patterns of anxiety disorder-associated genes
Anxiety disorders (ADs) are the most common form of mental disorder that affects millions of individuals worldwide. Although physiological studies...
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Prognostic value of oxidative phosphorylation-related genes in hepatocellular carcinoma
PurposeHepatocellular carcinoma (HCC) is the most prevalent malignancies worldwide. Recently, oxidative phosphorylation (OXPHOS) has received...
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Alzheimer’s Disease and Aging Association: Identification and Validation of Related Genes
BackgroundAging is considered a key risk factor for Alzheimer’s disease (AD). This study aimed to identify and validate potential aging-related genes...
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Integrative bioinformatics analysis to identify ferroptosis-related genes in non-obstructive azoospermia
PurposeThe objective of this study was to discern ferroptosis-related genes (FRGs) linked to non-obstructive azoospermia and investigate the...
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Transcriptomic analysis identifies diagnostic genes in polycystic ovary syndrome and periodontitis
PurposeTo investigate underlying co-mechanisms of PCOS and periodontitis through transcriptomic approach.
MethodsPCOS and periodontitis gene...
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Identification of genes that promote PI3K pathway activation and prostate tumour formation
We have performed a functional in vivo mutagenesis screen to identify genes that, when altered, cooperate with a heterozygous Pten mutation to...
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Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia
Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a master regulator...
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Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis
Recent studies have suggested that ferroptosis participates in various renal diseases. However, its effect on focal segmental glomerulosclerosis...
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Molecular map** of a core transcriptional signature of microglia-specific genes in schizophrenia
Besides playing a central role in neuroinflammation, microglia regulate synaptic development and is involved in plasticity. Converging lines of...
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Autophagy-related genes in mesial temporal lobe epilepsy: an integrated bioinformatics analysis
BackgroundAutophagy plays essential roles in the development and pathogenesis of mesial temporal lobe epilepsy (mTLE). In this research, we aim to...
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Identifying the tumor immune microenvironment-associated prognostic genes for prostate cancer
PurposeThis study aimed to explore novel tumor immune microenvironment (TIME)-associated biomarkers in prostate adenocarcinoma (PRAD).
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Epigenetic characterization of sarcopenia-associated genes based on machine learning and network screening
To screen characteristic genes related to sarcopenia by bioinformatics and machine learning, and to verify the accuracy of characteristic genes in...
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Differential Regulation of Immune-Related Genes in the Develo** Heart
In many congenital heart defects, it can be difficult to ascertain primary pathology from secondary consequences from altered flow through the...
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Recent advances in novel mutation genes of Parkinson's disease
With increasing life expectancy, a growing number of individuals are being affected by Parkinson's Disease (PD), a Neurodegenerative Disease (ND)....
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Identification of hub genes to determine drug-disease correlation in breast carcinomas
The exact molecular mechanism underlying the heterogeneous drug response against breast carcinoma remains to be fully understood. It is urgently...
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A multi-ancestry cerebral cortex transcriptome-wide association study identifies genes associated with smoking behaviors
Transcriptome-wide association studies (TWAS) have provided valuable insight in identifying genes that may impact cigarette smoking. Most of previous...
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Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder
Obsessive Compulsive Disorder (OCD) is listed as one of the top 10 most disabling neuropsychiatric conditions in the world. The neurobiology of OCD...
