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The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study
BackgroundAcute lymphoblastic leukemia (ALL) is the most common childhood cancer. Glutathione-S-methyl transferase ( GSTs ) enzymes’ family is known...
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Influence of glutathione S transferase A1 gene polymorphism (-69C > T, rs3957356) on intravenous cyclophosphamide efficacy and side effects: a case-control study in Egyptian patients with lupus nephritis
ObjectivesSystemic lupus erythematosus (SLE) is a systemic autoimmune disease. Cyclophosphamide (CYC) is a cytotoxic drug of a narrow therapeutic...
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Impact of retrograde intrarenal surgery on biomarkers that are associated with renal parenchyma injury, a preliminary study
PurposeThe primary objective of this preliminary study was to assess the changes in concentration of biomarkers, which indicate renal injury, after...
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Enhanced mosquitocidal efficacy of pyrethroid insecticides by nanometric emulsion preparation towards Culex pipiens larvae with biochemical and molecular docking studies
BackgroundThe growing threat of vector-borne diseases and environmental pollution with conventional pesticides has led to the search for...
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Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for various cancers for decades. However, its effectiveness...
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Phytochemical profile, comparative evaluation of Satureja montana alcoholic extract for antioxidants, anti-inflammatory and molecular docking studies
BackgroundThe most common species in the Satureja genus is Satureja montana (family Lamiaceae). The present work aims to use the molecular docking...
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Glucosinolates in cancer prevention and treatment: experimental and clinical evidence
Glucosinolates are naturally occurring β-d-thioglucosides that mainly exist in the Brassicaceae family. The enzyme myrosinase hydrolyzes...
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Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats
BackgroundNickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as...
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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
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Precision management of acute kidney injury in the intensive care unit: current state of the art
Acute kidney injury (AKI) is a prototypical example of a common syndrome in critical illness defined by consensus. The consensus definition for AKI,...
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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma
BackgroundGlioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH...
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Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of prostate cancer in Algerian population
BackgroundProstate cancer is the most common cancer in the world, and its etiology involves the interaction of genetic and environmental factors....
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To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance
Malaria remains a global health challenge with significant mortality and morbidity annually, with resistant parasite strains complicating treatment...
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Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans
Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies...
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Dicoumarol: from chemistry to antitumor benefits
Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as...
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Long non-coding RNAs: controversial roles in drug resistance of solid tumors mediated by autophagy
Current genome-wide studies have indicated that a great number of long non-coding RNAs (lncRNAs) are transcribed from the human genome and appeared...
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Expression and 7-day time course of circulating microRNAs in septic patients treated with nephrotoxic antibiotic agents
BackgroundThrough regulation of signaling pathways, microRNAs (miRNAs) can be involved in sepsis and associated organ dysfunction. The aims of this...
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Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to...
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Extrahepatic metabolism of ibrutinib
Ibrutinib is a first-in-class Bruton’s kinase inhibitor used in the treatment of multiple lymphomas. In addition to CYP3A4-mediated metabolism,...
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Nucleic acid-based drugs for patients with solid tumours
The treatment of patients with advanced-stage solid tumours typically involves a multimodality approach (including surgery, chemotherapy,...
