Search
Search Results
-
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) differentiation and function....
-
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell...
-
TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
Colorectal cancer (CRC) is one of the highest mortality rates worldwide, and various studies reported to the occurrence of CRC. In particular, the...
-
WNT/β-catenin regulatory roles on PD-(L)1 and immunotherapy responses
Dysregulation of WNT/β-catenin is a hallmark of many cancer types and a key mediator of metastasis in solid tumors. Overactive β-catenin signaling...
-
Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway
BackgroundCholangiocarcinoma (CCA) is a refractory malignancy derived from bile duct epithelial cells. This study aimed to explore the role and...
-
Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells
ObjectiveMitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a critical role in regulating mitochondrial fusion and cellular...
-
Gastrodin inhibits prostate cancer proliferation by targeting canonical Wnt/β-catenin signaling pathway
Prostate cancer is an epithelial malignant tumor occurring in the prostate and is the most common malignant tumor in the male genitourinary system....
-
WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling
Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of cancer-related death among men. A comprehensive understanding...
-
SAA1 regulated by S1P/S1PR1 promotes the progression of ESCC via β-catenin activation
Serum amyloid A1 (SAA1), an inflammation-related molecule, is associated with the malignant progression of many tumors. This study aimed to...
-
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity
The Wnt/β-catenin signaling is usually abnormally activated in hepatocellular carcinoma (HCC), and pituitary tumor-transforming gene 1 (PTTG1) has...
-
Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior
The Wnt/β-catenin pathway contains multiple high-confidence risk genes that are linked to neurodevelopmental disorders, including autism spectrum...
-
Proteomic analysis of the develo** mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway
Clustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein...
-
Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis
BackgroundWilforine (WFR) is a monomeric compound of the anti-RA plant Tripterygium wilfordii Hook. f. (TwHF). Whether WFR has anti-RA effect, its...
-
Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(−/−) mice
ObjectiveTo investigate the role of urantide in the prevention and treatment of atherosclerosis (AS)-related liver and kidney injury by antagonizing...
-
β-asarone attenuates the proliferation, migration and enhances apoptosis of retinoblastoma through Wnt/β-catenin signaling pathway
Purposeβ-asarone is the prime component of essential oil extracted from Acori graminei Rhizoma, which plays an inhibitory role in various tumors....
-
The WNT/β-catenin system in chronic kidney disease-mineral bone disorder syndrome
BackgroundThe WNT/β-catenin system is an evolutionarily conserved signaling pathway that plays a crucial role in morphogenesis and cell tissue...
-
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway
ObjectiveUterine corpus endometrial carcinoma (UCEC), a kind of gynecologic malignancy, poses a significant risk to women’s health. The precise...
-
Quantitative radiomics and qualitative LI-RADS imaging descriptors for non-invasive assessment of β-catenin mutation status in hepatocellular carcinoma
PurposeGain-of-function mutations in CTNNB1 , gene encoding for β-catenin, are observed in 25–30% of hepatocellular carcinomas (HCCs). Recent studies...
-
Overexpression of FHL1 suppresses papillary thyroid cancer proliferation and progression via inhibiting Wnt/β-catenin pathway
PurposeThe four and a half LIM domain protein 1 (FHL1) has been found to act as a tumor suppressor in several cancers. However, the clinical and...
-
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin
Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic cancer. Family with sequence...
