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First-in-human validation of a DROP-IN β-probe for robotic radioguided surgery: defining optimal signal-to-background discrimination algorithm
PurposeIn radioguided surgery (RGS), radiopharmaceuticals are used to generate preoperative roadmaps (e.g., PET/CT) and to facilitate intraoperative...
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Radio-Guided Surgery with a New-Generation β-Probe for Radiolabeled Somatostatin Analog, in Patients with Small Intestinal Neuroendocrine Tumors
BackgroundRadio-guided surgery (RGS) holds promise for improving surgical outcomes in neuroendocrine tumors (NETs). Previous studies showed low...
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Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging
BackgroundThe molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress...
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A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
BackgroundHeat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and...
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Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and...
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B-Glycine as a marker for β cell imaging and β cell mass evaluation
Purposeβ cell mass (BCM) and function are essential to the diagnosis and therapy of diabetes. Diabetic patients serve β cell loss is, and damage of β...
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Synthesis and evaluation of [18F]FBNAF, a STAT3-targeting probe, for PET imaging of tumor microenvironment
BackgroundSignal transducer and activator of transcription 3 (STAT3) is a protein that regulates cell proliferation and differentiation, and it is...
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Phenotypic drug susceptibility characterization and clinical outcomes of tuberculosis strains with A-probe mutation by GeneXpert MTB/RIF
BackgroundGeneXpert MTB/RIF (Xpert) assay was applied widely to detect Mycobacterium tuberculosis (MTB) and rifampicin resistance.
Methods ...
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A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model
PurposeNoninvasive imaging of protein aggregates in the brain is critical for the early diagnosis, disease monitoring, and evaluation of the...
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Development of a novel 18F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression
AbstractThe mesenchymal epithelial transition factor (c-Met) is frequently overexpressed in numerous cancers and has served as a validated anticancer...
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Targeted delivery of nuclear targeting probe for bladder cancer using cyclic pentapeptide c(RGDfK) and acridine orange
PurposeBoth cyclic pentapeptide c(RGDfK) and acridine orange (AO) exhibit antitumor effects and cell permeability. This study aimed to evaluate the...
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Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy. The...
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CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults
Background and ObjectiveVoriconazole is an important broad-spectrum anti-fungal drug with nonlinear pharmacokinetics. The aim of this single centre...
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A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
PurposeFibroblast activation protein inhibitor (FAPI) -based probes have been widely studied in the diagnosis of various malignant tumors with...
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Early diagnostic value of ECT whole-body bone imaging combined with PINP and β-CTX for bone metastasis of lung cancer
ObjectiveThis research was aimed at investigating the early diagnostic value of emission computed tomograph (ECT) whole-body bone imaging combined...
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Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis
Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly...
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Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course
BackgroundCatenin (Cadherin-Associated Protein), Beta 1 ( CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations...
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XRelevanceCAM: towards explainable tissue characterization with improved localisation of pathological structures in probe-based confocal laser endomicroscopy
PurposeProbe-based confocal laser endomicroscopy (pCLE) enables intraoperative tissue characterization with improved resection rates of brain...
