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Selected coffee (Coffea arabica L.) extracts inhibit intestinal α-glucosidases activities in-vitro and postprandial hyperglycemia in SD Rats
One of the therapeutic approaches for decreasing postprandial hyperglycemia is to retard absorption of glucose by the inhibition of carbohydrate...
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Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
BackgroundNatural products are utilized globally for the management of diseases such as diabetes mellitus. Carrot seeds are ethnobotanically used in...
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Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study
Background/ObjectivesGlucose tolerance is controlled by the internal clock and is worse in the evening. From a chrononutrition perspective, diabetes...
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Insilico screening and pharmacokinetic properties of phytoconstituents from Ferula asafoetida H.Karst. (Heeng) as potential inhibitors of α-amylase and α-glucosidase for Type 2 Diabetes Mellitus
PurposeFerula asafoetida H.Karst. commonly known as Heeng in India belong to family Umbelliferae ( Apiaceae ) and has been known for neuroprotective,...
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Antidiabetic potential of Lysiphyllum strychnifolium (Craib) A. Schmitz compounds in human intestinal epithelial Caco-2 cells and molecular docking-based approaches
BackgroundLysiphyllum strychnifolium (Craib) A. Schmitz, a traditional Thai medicinal plant, is mainly composed of polyphenols and flavonoids and...
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A novel nutritional supplement reduces postprandial glucose response in healthy individuals in a randomised, placebo-controlled, crossover clinical study
BackgroundSugar-laden foods and carbohydrate-rich diets with high glycaemic index intake are associated with weight gain, increased incidence of...
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Molecular interaction of bioactive compounds from Senecio biafrae leaf with α-amylase and α-glucosidase receptors
BackgroundDiabetes mellitus is one of the silent killer diseases affecting millions of people globally and some of the key enzymes in managing this...
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Protein glycosylation in cardiovascular health and disease
Protein glycosylation, which involves the attachment of carbohydrates to proteins, is one of the most abundant protein co-translational and...
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Cipaglucosidase Alfa: First Approval
Cipaglucosidase alfa (Pombiliti ™ ) is a recombinant human acid α-glucosidase (GAA) product being developed by Amicus Therapeutics along with the...
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Sucrase-Isomaltase Deficiency: Hiding in Plain Sight?
Purpose of reviewOur review focuses on the various presentations, diagnosis, and treatment of sucrose–isomaltase deficiency (SID), previously thought...
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Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
This review article gives an insight into the genetic factors and the role of pancreatic amylase in type 2 diabetes (T2D). Diabetes is a...
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HPLC fingerprint of flavonoids, enzyme inhibition and antioxidant activity of Newbouldia laevis stem-bark: an in vitro and in silico study
BackgroundMedicinal plant contains multiple bioactive compounds with therapeutic potentials. Due to their availability, affordability, and minimal...
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Causal effects of gut microbiome on endometriosis: a two-sample mendelian randomization study
BackgroundPrevious studies have shown observational associations between the gut microbiota and endometriosis; however, the causal nature of such...
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An investigationof the inhibitory effects of dichloromethane and methanol extracts of Salvia macilenta, Salvia officinalis, Salvia santolinifola and Salvia mirzayanii on diabetes marker enzymes, an approach for the treatment diabetes
BackgroundDiabetes mellitus is a type of metabolic disease characterized by elevated blood sugar. The main strategy for its treatment is to inhibit...
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Higher mitochondrial DNA copy number is associated with metformin-induced weight loss
BackgroundConsiderable variability exists in response to metformin with few effective biomarkers to guide the treatment. Here we evaluated whether...
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A Randomized, Placebo-Controlled Crossover Study to Evaluate Postprandial Glucometabolic Effects of Mulberry Leaf Extract, Vitamin D, Chromium, and Fiber in People with Type 2 Diabetes
IntroductionReducing postprandial (PP) hyperglycemia and PP glucose excursions is important for overall glycemic management. Although most...
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Molecular study of Pompe disease in Egyptian infants
BackgroundPompe disease (PD) is a serious genetic disorder caused by deficiency of acid α-glucosidase (GAA) and subsequent glycogen accumulation...
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Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the...
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Avalglucosidase alfa: First Approval
Avalglucosidase alfa (NEXVIAZYME™; avalglucosidase alfa-ngpt) is a hydrolytic lysosomal glycogen-specific recombinant human α-glucosidase product...
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Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF-κB pathway
BackgroundType 2 diabetes mellitus (T2DM) approximately constitutes 90% of the reported cases. 30-40% of diabetics eventually develop diabetic...
