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1. Three-column osteotomy in long constructs has lower rates of proximal junctional kyphosis and better restoration of lumbar lordosis than anterior column realignment

   Purpose

   Three-column osteotomies (TCOs) and minimally invasive techniques such as anterior column realignment (ACR) are powerful tools used to restore...

   Elliot Pressman, Molly Monsour, ... Puya Alikhani in European Spine Journal

   Article 15 January 2024
   

2. In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with astatine-211

   Background

   A significant challenge in cancer therapy lies in eradicating hidden disseminated tumor cells. Within Nuclear Medicine, Targeted Alpha...

   Chiara Timperanza, Holger Jensen, ... Emma Aneheim in EJNMMI Radiopharmacy and Chemistry

   Article Open access 22 May 2024
   

3. Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

   Background

   Trans -cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand...

   Karuna Adhikari, Maarten Vanermen, ... Filipe Elvas in EJNMMI Radiopharmacy and Chemistry

   Article Open access 06 June 2024
   

4. Applying Practice Analysis to Develop a New Test Content Outline for the Pediatric Cardiology Certification Examination

   The evolving breadth and complexity of the contemporary pediatric cardiology specialty requires regular, systematic analysis of the practice to...

   Robert C. Brucia, Nathaniel W. Taggart, ... Audrey C. Marshall in Pediatric Cardiology

   Article 12 December 2022
   

5. Pathogenicity and vaccine efficacy of two virulent infectious laryngotracheitis virus strains in Egypt

   Infectious laryngotracheitis (ILT) is an economically crucial respiratory disease of poultry that affects the industry worldwide. Vaccination is the...

   Mohamed El-Saied, Magdy M. El-Mahdy, ... Mohamed Shaalan in BMC Veterinary Research

   Article Open access 26 September 2022
   

6. Outcomes of Three Different Minimal Invasive Approaches for Secundum Atrial Septal Defect Closure: A Single Institute Experience

   Objective: The aims of this retrospective study were to investigate and evaluate the safety and efficacy of three approaches for closure of secundum...

   Hao Hong, Long Wu, ... Nian-guo Dong in Current Medical Science

   Article 28 November 2021

7. Influence of COVID-19 on the 10-year carbon footprint of the Nagoya University Hospital and medical research centre

   Background:

   Amidst the climate crisis, a key goal of the medical sector is to reduce its large carbon footprint. Although the Coronavirus disease 2019...

   Hikaru Morooka, Takanori Yamamoto, ... Shoichi Maruyama in Globalization and Health

   Article Open access 07 November 2022
   

8. Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging

   Background

   Combining optical (fluorescence) imaging with nuclear imaging has the potential to offer a powerful tool in personal health care, where...

   Anthony W. McDonagh, Brooke L. McNeil, ... Caterina F. Ramogida in EJNMMI Radiopharmacy and Chemistry

   Article Open access 06 June 2022
   

9. Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

   Background

   Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron...

   Olivia Wegrzyniak, Bo Zhang, ... Olof Eriksson in EJNMMI Radiopharmacy and Chemistry

   Article Open access 21 September 2023
   

10. A Pretargeted Imaging Strategy for EGFR-Positive Colorectal Carcinoma via Modulation of Tz-Radioligand Pharmacokinetics

    Purpose

    Previously, we successfully developed a pretargeted imaging strategy (atezolizumab-TCO/[ ^99m Tc]HYNIC-PEG ₁₁ -Tz) for evaluating programmed cell...

    Lin Qiu, Qingyu Lin, ... Hongcheng Shi in Molecular Imaging and Biology

    Article 10 September 2020
    

11. Associations of the Serum Total Carbon Dioxide Level with Long-Term Clinical Outcomes in Sepsis Survivors

    Introduction

    Sepsis is characterized by a dysregulated host response to infection that leads to multiple organ dysfunction and often complicated with...

    Ching Han Yang, Yee-An Chen, ... Der-Cherng Tarng in Infectious Diseases and Therapy

    Article Open access 07 February 2023
    

12. Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells

    Background

    Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1...

    Pierre Cheung, Julia Thorngren, ... Olof Eriksson in EJNMMI Research

    Article Open access 15 December 2023
    

13. Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

    Background

    The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of...

    Eva Schlein, Johanna Rokka, ... Jonas Eriksson in EJNMMI Radiopharmacy and Chemistry

    Article Open access 06 March 2024
    

14. Examination of the PET in vivo generator ¹³⁴Ce as a theranostic match for ²²⁵Ac

    Purpose

    The radionuclide pair cerium-134/lanthanum-134 ( ¹³⁴ Ce/ ¹³⁴ La) was recently proposed as a suitable diagnostic counterpart for the therapeutic...

    David Bauer, Roberto De Gregorio, ... Jason S. Lewis in European Journal of Nuclear Medicine and Molecular Imaging

    Article 28 June 2024
    

15. The need for an expanded, evidence-based public health response to the overdose crisis and the toxic drug supply in Canada

    Elaine Hyshka, David M. Moore, ... Karen Urbanoski in Canadian Journal of Public Health

    Article 01 April 2024

16. Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry

    Purpose

    The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide...

    Brendon E. Cook, Jonathan Archbold, ... Maciej Kaliszczak in Molecular Imaging and Biology

    Article 02 June 2022
    

17. A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry

    Purpose

    The use of antibodies as tracers requires labeling with isotopes with long half-lives due to their slow pharmacokinetics, which creates...

    Lin Qiu, Hui Tan, ... Hongcheng Shi in Molecular Imaging and Biology

    Article 18 November 2019
    

18. Einführungsstrategie für ein Dosismanagementsystem

    We present the different steps for procurement of a dose management system for a university hospital, starting from the Europe-wide request for...

    Georg Stamm, Hans-Werner Rübel in Der Radiologe

    Article 17 December 2020

19. Development of an ¹⁸F-labeled anti-human CD8 VHH for same-day immunoPET imaging

    Purpose

    Cancer immunotherapies (CITs) have revolutionized the treatment of certain cancers, but many patients fail to respond or relapse from current...

    Shravan Kumar Sriraman, Christopher W. Davies, ... Simon Peter Williams in European Journal of Nuclear Medicine and Molecular Imaging

    Article 08 November 2022
    

20. Recent advances in develo** active targeting and multi-functional drug delivery systems via bioorthogonal chemistry

    Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic...

    Wenzhe Yi, ** ** Li in Signal Transduction and Targeted Therapy

    Article Open access 02 December 2022