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Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease
ObjectiveTo evaluate ITPKC and NLRP3 expression in children with Kawasaki disease (KD) and investigate the relationship between serum...
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Improved synthesis of 6-bromo-7-[11C]methylpurine for clinical use
BackgroundMultidrug resistance-associated protein 1 (MRP1), an energy-dependent efflux pump, is expressed widely in various tissues and contributes...
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tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice
DNA cytosine methylation has been documented as a potential epigenetic mechanism of transcriptional regulation underlying opioid use disorder....
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Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer
PurposeColorectal cancer (CRC) is one of the most common malignancies, with a high incidence and mortality worldwide. Methylated Septin 9 (mSEPT9)...
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Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma
BackgroundLiver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have previously reported that differentially methylated...
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N6-methyladenosine RNA methylation in liver diseases: from mechanism to treatment
Epigenetic modification occurring in RNA has become the hotspot of the field. N 6-methyladenosine (m6A) methylation is the most abundant RNA internal...
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A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis
BackgroundGenetic and epigenetic factors are associated with the development of alcohol-associated liver disease (AALD). The single nucleotide...
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Evaluation of CX3CR1 gene DNA methylation in developmental dysplasia of the hip (DDH)
Introduction and objectiveDevelopmental dysplasia of the hip (DDH) is a musculoskeletal disorder. Genetic and epigenetic changes in C-X3-C motif...
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Associations of methylene tetrahydrofolate reductase (MTHFR) polymorphism with hepatocellular carcinoma in Egyptian population
Liver serves as a hub for key metabolic pathways such as folate cycle that provides one-carbon units for a network of metabolic reactions....
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Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk
BackgroundOsteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the...
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Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence
BackgroundTransitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of...
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Integrated investigation of the clinical implications and targeted landscape for RNA methylation modifications in hepatocellular carcinoma
BackgroundRNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N 1 -methyl...
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Early detection and stratification of lung cancer aided by a cost-effective assay targeting circulating tumor DNA (ctDNA) methylation
BackgroundDetection of lung cancer at earlier stage can greatly improve patient survival. We aim to develop, validate, and implement a cost-effective...
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DNA methylation and transcription of the FOXO3a gene are associated with ankylosing spondylitis
To explore the association between methylation level and transcript level of Forkhead box O3a (FOXO3a) gene with ankylosing spondylitis (AS)...
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Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis
BackgroundEpigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study...
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The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter region
Avian leukosis virus subgroup J (ALV-J) can cause neoplastic diseases in poultry and is still widely prevalent in China. Chicken telomerase reverse...
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Integrative analysis with machine learning identifies diagnostic and prognostic signatures in neuroblastoma based on differentially DNA methylated enhancers between INSS stage 4 and 4S neuroblastoma
IntroductionAccumulating evidence demonstrates that aberrant methylation of enhancers is crucial in gene expression profiles across several cancers....
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YTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs
BackgroundWith the increasing incidence of steroid-induced necrosis of the femoral head (SNFH), numerous scholars have investigated its pathogenesis....
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Genetic and epigenetic alterations in MGMT gene and correlation with concomitant chemoradiotherapy (CRT) in cervical cancer
PurposeThe MGMT (O 6 -methylguanine-DNA methyltransferase) gene plays a crucial role in repairing DNA damage caused by alkylating agents, including...
