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Radiomic analysis will add differential diagnostic value of benign and malignant pulmonary nodules: a hybrid imaging study based on [18F]FDG and [18F]FLT PET/CT
PurposeTo investigate the clinical value of radiomic analysis on [ 18 F]FDG and [ 18 F]FLT PET on the differentiation of [ 18 F]FDG-avid benign and...
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Hematopoiesis in the spleen after engraftment in unrelated cord blood transplantation evaluated by 18F-FLT PET imaging
Cord blood is an important donor source for allogeneic hematopoietic stem cell transplantation (allo-HSCT), with its unique composition and quality...
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Comparison of the [18F]-FDG and [18F]-FLT PET Tracers in the Evaluation of the Preclinical Proton Therapy Response in Hepatocellular Carcinoma
PurposeThe main objective of the present study was to compare the 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]-FDG) and 3′-[ 18 F]fluoro-3′-deoxythymidine ([
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18F-FLT PET/CT imaging for early monitoring response to CDK4/6 inhibitor therapy in triple negative breast cancer
PurposeOur study was to investigate 18 F-FLT PET/CT imaging monitor the early response of CDK4/6 inhibitor therapy in triple negative breast cancer...
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Voxel-Based Analysis of the Relation of 3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) PET and Diffusion-Weighted (DW) MR Signals in Subcutaneous Tumor Xenografts Does Not Reveal a Direct Spatial Relation of These Two Parameters
PurposeMultimodal molecular imaging allows a direct coregistration of different images, facilitating analysis of the spatial relation of various...
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High efficacy of particle beam therapies against tumors under hypoxia and prediction of the early stage treatment effect using 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography
ObjectiveCompared with radiation therapy using photon beams, particle therapies, especially those using carbons, show a high relative biological...
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18F-fluorothymidine (FLT)-PET and diffusion-weighted MRI for early response evaluation in patients with small cell lung cancer: a pilot study
BackgroundSmall cell lung cancer (SCLC) is an aggressive cancer often presenting in an advanced stage and prognosis is poor. Early response...
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Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy
BackgroundThe goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues....
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Dual time point [18F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues
PurposeFor differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([ 18 F]FDG) dual time point PET could be helpful. Albeit [ 18 ...
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Evaluating the Accuracy of FUCCI Cell Cycle In Vivo Fluorescent Imaging to Assess Tumor Proliferation in Preclinical Oncology Models
PurposeThe primary goal of this study is to evaluate the accuracy of the fluorescence ubiquitination cell cycle indicator (FUCCI) system with...
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Diagnostic value of PET/CT with 11C-methionine (MET) and 18F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification
BackgroundThe molecular features of isocitrate dehydrogenase ( IDH ) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role...
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18F-FLT PET/MRI for bone marrow failure syndrome-initial experience
BackgroundBone marrow failure syndrome (BMFS) is a heterogeneous group of disorders associated with single- or multiple-lineage cytopenia and failure...
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Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm
BackgroundAbdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation...
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Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Lung cancer has the highest mortality rate of any tumour type. The main driver of lung tumour growth and development is uncontrolled cellular...
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Screening of radiotracer for diagnosis of colorectal cancer liver metastasis based on MACC1-SPON2
BackgroundMetastasis-associated in colon cancer 1 (MACC1) and Spondin2 (SPON2) are newly discovered oncogenes, but little is known about their role...
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Exploring the applicability of a lesion segmentation method on [18F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma
Background and purposeThe determination of the total metabolic tumour volume based on [ 18 F]fluorothymidine ([ 18 F]FLT) PET/CT images in diffuse large...
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Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model
PurposeA reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of...