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Von Artemisia annua L. zu Artemisininen Die Entdeckung und Entwicklung von Artemisininen und Malariamedikamenten
Malaria ist seit jeher eine schwere epidemische Krankheit. In den 1820er Jahren entdeckten westliche Wissenschaftler einen wirksamen antimalariösen...
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Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study
BackgroundAnti-programmed cell death-1 (ligand-1) antibody [PD-(L)1-Ab] can cause destructive thyroiditis and/or hypothyroidism. In addition,...
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L-DOPA-therapy in Parkinson’s disease: some personal reflections on L-DOPA therapy from Vienna and Berlin
Dopamine was initially considered as a mere intermediate in the noradrenaline synthesis but was then found to be a neurotransmitter. Its depletion...
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Der lokalisierte tenosynoviale Riesenzelltumor (L-TSRZT)
BackgroundThe tenosynovial giant cell tumor (pigmented villonodular synovitis) is a proliferative, mainly benign soft tissue tumor of the tendon...
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First-line hepatic arterial infusion chemotherapy plus lenvatinib and PD-(L)1 inhibitors versus systemic chemotherapy alone or with PD-(L)1 inhibitors in unresectable intrahepatic cholangiocarcinoma
PurposeLimited treatment options exist for unresectable intrahepatic cholangiocarcinoma (ICC), with systemic chemotherapy (SC) serving as the primary...
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Multi-dose enteral L-citrulline administration in premature infants at risk of develo** pulmonary hypertension associated with bronchopulmonary dysplasia
ObjectiveInformation is needed to guide the design of randomized controlled trials (RCTs) evaluating L-citrulline therapy for premature infants with...
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3 L split-dose polyethylene glycol is superior to 2 L polyethylene glycol in colonoscopic bowel preparation in relatively high-BMI (≥ 24 kg/m2) individuals: a multicenter randomized controlled trial
BackgroundWhether body mass index (BMI) is a risk factor for poor bowel preparation is controversial, and the optimal bowel preparation regimen for...
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Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and...
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L-Strut Cartilage Graft: A Versatile Graft in Functional Rhinoplasty
Anterior and high septal deviation can severely affect the functional and cosmetic outcomes of a patient. Conventional septoplasty would not be...
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L-Arginine in diabetes: clinical and preclinical evidence
L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus...
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L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats
BackgroundPrenatal or postnatal lung inflammation and oxidative stress disrupt alveolo-vascular development leading to bronchopulmonary dysplasia...
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Investigation of antileishmanial activities of CaO nanoparticles on L. tropica and L. infantum parasites, in vitro
Stibogluconate sodium and meglumine antimoniate are the main antimonials utilised as the primary treatment option for leishmaniasis. However, have a...
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The VRF-L and VRF-GL IOL power calculation methods after radial keratotomy
BackgroundTo investigate the accuracy of the VRF-L and VRF-GL IOL power calculation methods in cataract surgery after radial keratotomy (RK).
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Indonesia youth population norms for EQ-5D-Y-3 L, EQ-5D-Y-5 L and the PedsQL generic core scale: lower health related quality of life relates to high economic status and stress
BackgroundThe availability of population norms from generic health-related quality of life (HRQoL) instruments can support the interpretation of...
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Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an important locus of fear extinction-facilitating...
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Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial
BackgroundColonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to...
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Predictive factors for l-asparaginase hypersensitivity in pediatric acute lymphoblastic leukemia
Backgroundl -Asparaginase is a crucial component of acute lymphoblastic leukemia (ALL) treatment. However, hypersensitivity is a common adverse...
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L-cysteine contributes to destructive activities of odontogenic cysts/tumor
BackgroundOdontogenic cysts/tumor can cause severe bone destruction, which affects maxillofacial function and aesthetics. Meanwhile, metabolic...
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Natural L-type calcium channels antagonists from Chinese medicine
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca 2+ influx during...
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Common food additive carrageenan inhibits proglucagon expression and GLP-1 secretion by human enteroendocrine L-cells
Proglucagon mRNA expression and GLP-1 secretion by cultured human L-cells (NCI-H716) were inhibited following exposure to λ-carrageenan, a commonly...
