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Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives
MicroRNAs (miRNAs) are a class of short single-stranded, noncoding RNAs that affect the translation of mRNAs by imperfectly binding to homologous...
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MN1 altered astroblastoma with APC and LRP1B gene mutations: a unique variant in the cervical spine of a pediatric patient
PurposeAstroblastomas (AB) are high-grade neoplasms which typically occur within the cerebral hemisphere. However, given the rarity of this neoplasm...
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Regeneration des Sehnerven – Wird das einmal Realität?
BackgroundAdult mammalian and human neurons of the central nervous system (CNS) lack the ability to spontaneously regenerate damaged axons. This...
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TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer
The Tripartite motif-containing 28 (TRIM28) transcriptional cofactor is significantly upregulated in high-grade and metastatic prostate cancers. To...
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Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients
BackgroundBiallelic mutations in CYP27A1 and CYP7B1 , two critical genes regulating cholesterol and bile acid metabolism, cause cerebrotendinous...
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Identification of key tumor stroma-associated transcriptional signatures correlated with survival prognosis and tumor progression in breast cancer
BackgroundThe aberrant expression of stromal gene signatures in breast cancer has been widely studied. However, the association of stromal gene...
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Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis
Mucin4 (MUC4) appears early during pancreatic intraepithelial neoplasia-1 (PanIN1), coinciding with the expression of epidermal growth factor...
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Effects of atorvastatin on the function of Tenon’s capsule fibroblasts in human eyes
PurposeThis study aimed to explore the role of atorvastatin (ATO) in the prevention and treatment of the scarring of filtration channels after...
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Basic Epigenetic Mechanisms of Aging
AbstractThe process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and...
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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis
Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested by increased endogenous fat mobilization,...
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Histo-molecular characterization of pancreatic cancer with microsatellite instability: intra-tumor heterogeneity, B2M inactivation, and the importance of metastatic sites
Pancreatic ductal adenocarcinoma (PDAC) with microsatellite instability (MSI)/defective mismatch repair (dMMR) is the only subtype of pancreatic...
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Gender differences in microRNA expression in levodopa-naive PD patients
Gender is an important factor influencing epidemiological and clinical features of Parkinson’s disease (PD). We aimed to evaluate gender differences...
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Stammzellen für die Wiederherstellung der endogenen Insulinsekretion
Despite modern insulin therapies, there are patients whose diabetes is not well controlled. Such patients suffer from hypoglycaemic episodes and are...
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Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4
BackgroundBM-MSCs play an important role in cancer development through the release of cytokines or exosomes. Studies have shown that extracellular...
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Diabetes Mellitus to Accelerated Atherosclerosis: Shared Cellular and Molecular Mechanisms in Glucose and Lipid Metabolism
Diabetes is one of the critical independent risk factors for the progression of cardiovascular disease, and the underlying mechanism regarding this...
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Exploring the Inner Workings of Direct Cardiac Reprogramming
Purpose of ReviewFollowing cardiac injury, the heart has limited ability to regenerate leading to decreased efficiency and function. Cardiac...
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Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac...
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Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells
Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to...
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RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development
BackgroundSecreted R-spondin (RSPO) proteins play a key role in reproductive organ development, epithelial stem cell renewal and cancer induction by...
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Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review
During eukaryotic gene expression, alternative splicing of messenger RNA precursors is critical in increasing protein diversity and regulatory...
