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Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo
Mixed lineage leukemias (MLLs) are human histone H3 lysine-4-specific methyl transferases that have critical roles in gene expression, epigenetics...
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Deregulated transcription factors in leukemia
Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and...
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The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia
Translocations involving the mixed-lineage leukemia ( MLL ) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML)...
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Mutation spectrum of MLL2 in a cohort of kabuki syndrome patients
BackgroundKabuki syndrome (Niikawa-Kuroki syndrome) is a rare, multiple congenital anomalies/mental retardation syndrome characterized by a peculiar...
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Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells
MOZ and MLL , encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal...
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The heterodimerization domains of MLL—FYRN and FYRC—are potential target structures in t(4;11) leukemia
The chromosomal translocation t(4;11)(q21;q23) is a frequent genetic aberration of the mixed lineage leukemia ( MLL) gene, predominantly associated...
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The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures
Expression of the AF4–MLL fusion protein in murine hematopoietic progenitor/stem cells results in the development of proB acute lymphoblastic...
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Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53
Mixed lineage leukemia 5 (MLL5) has been implicated in multiple aspects of cell physiology, such as hematopoiesis, cell cycle control and chromatin...
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Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
SummaryWe investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone...
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Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation
Understanding the mechanisms that link changes in DNA methylation with histone modifications is particularly relevant in the case of tumor suppressor...
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Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes
Constitutive nuclear factor (NF)-κB activation in haematological malignancies is caused in several cases by loss of function mutations within the...
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Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2
The mixed-lineage leukemia (MLL) family of histone methyltransferases has become notorious for the participation of the founding member, MLL, in...
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Young carers in Germany: to live on as normal as possible – a grounded theory study
BackgroundIn contrast to a growing body of research on the situation of adult family care givers, in Germany hardly anything is known about the...
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Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
We performed a genome-wide analysis of promoter associated CpG island methylation using methylated CpG island amplification (MCA) coupled to...
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Males absent on the first (MOF): from flies to humans
Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic...
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Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia
Fusion of the mixed lineage leukemia protein (MLL) to one of over 50 different translocation partners converts it into a potent leukemogenic...
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Mechanisms of Disease: multiple endocrine neoplasia type 1—relation to chromatin modifications and transcription regulation
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by tumors of the parathyroid glands, the pancreatic islets,...
