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Cellular senescence and acute kidney injury
Acute kidney injury (AKI) is a common clinical complication characterized by a sudden deterioration of the kidney’s excretory function, which...
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Erythrose inhibits the progression to invasiveness and reverts drug resistance of cancer stem cells of glioblastoma
Glioblastoma (GBM) is the most frequent brain cancer and more lethal than other cancers. Characteristics of this cancer are its high drug resistance,...
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Role of PPAR-related genes in chronic heart failure: evidence from large populations
BackgroundThe role of PPAR signaling and its associated genes in the pathogenesis and progression of chronic heart failure (CHF) remains elusive.
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Delineating the role of nuclear receptors in colorectal cancer, a focused review
Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million...
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Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression
Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of...
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Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease
Diabetic heart disease (DHD) is a serious complication in patients with diabetes. Despite numerous studies on the pathogenic mechanisms and...
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OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell
Prostate cancer (PCa) is the second leading disease of cancer-related death in men around the world, and it is almost impossible to treat advanced...
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The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis
Ferroptosis is characterized by the accumulation of lipid peroxidation as a unique iron-dependent cell death. However, the interplay between stemness...
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Differential Salmonella Typhimurium intracellular replication and host cell responses in caecal and ileal organoids derived from chicken
Chicken infection with Salmonella Typhimurium is an important source of foodborne human diseases. Salmonella colonizes the avian intestinal tract and...
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Phenotypic diversity and metabolic specialization of renal endothelial cells
Complex multicellular life in mammals relies on functional cooperation of different organs for the survival of the whole organism. The kidneys play a...
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Switching of vascular cells towards atherogenesis, and other factors contributing to atherosclerosis: a systematic review
BackgroundOnset, development and progression of atherosclerosis are complex multistep processes. Many aspects of atherogenesis are not yet properly...
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Signaling pathways in brain tumors and therapeutic interventions
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages. Although there are few therapeutic options for brain tumors,...
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A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism
BackgroundOsteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and...
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MN1 altered astroblastoma with APC and LRP1B gene mutations: a unique variant in the cervical spine of a pediatric patient
PurposeAstroblastomas (AB) are high-grade neoplasms which typically occur within the cerebral hemisphere. However, given the rarity of this neoplasm...
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Current understanding of ELF4 deficiency: a novel inborn error of immunity
BackgroundELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity (IEIs), specifically...
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Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) biomarker studies rarely employ multi-omic biomarker strategies and pertinent clinicopathologic characteristics...
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Radiotherapy for meningiomas
Meningiomas are the most common primary central nervous system neoplasm. Despite promising recent progress in elucidating the genomic landscape and...
