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Comparison of the Impact of Immune-Related Adverse Events Due to Immune Checkpoint Inhibitor Dual Combination Therapy and Immune Checkpoint Inhibitor Plus Tyrosine Kinase Inhibitor Combination Therapy in Patients with Advanced Renal Cell Carcinoma
BackgroundThe prognostic impact of immune-related adverse events during immune checkpoint inhibitor-based combination therapy for advanced renal cell...
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SGLT-2 inhibitors and atrial fibrillation in the Food and Drug Administration adverse event reporting system
BackgroundSodium glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk of heart failure and new data show they can prevent atrial fibrillation...
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Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery
BackgroundMajor adverse cardiovascular events (MACE) are critical complications responsible for the morbidity and mortality of elderly hip fracture...
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Severe cutaneous adverse reactions
Severe cutaneous adverse reactions (SCARs), which include Stevens–Johnson syndrome and toxic epidermal necrolysis, drug reaction with eosinophilia...
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Ventricular-arterial decoupling is associated with in-hospital adverse events in normotensive pulmonary embolism
During acute pulmonary embolism (PE) a compensatory increase in right ventricular (RV) contractility is required to match increased afterload to...
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Emergence of psychiatric adverse events during antipsychotic treatment in AP-naïve children and adolescents
BackgroundOver the last decades, antipsychotic prescriptions in children have increased worldwide. However, adverse events are frequently observed,...
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Oxygen Uptake Efficiency Slope Predicts Adverse Outcome Following Atrial Switch Procedure
Prior to the 1990s, d-TGA was palliated with the atrial switch procedure resulting in a systemic right ventricle associated with significant...
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Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review
Background and ObjectivesDespite the evidence that no other antipsychotic is effective as clozapine for the treatment of resistant schizophrenia, it...
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Analysis of Reported Adverse Events Associated with Over-the-Scope Endoscopic Suturing System: an FDA MAUDE Database Study
PurposeThe over-the-scope endoscopic suturing system (ESS) (OverStitch™) is one of the most widely utilized endoscopic suturing systems in current...
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Understanding the Medical Dictionary for Regulatory Activities (MedDRA) reporting of herpes simplex virus (HSV) adverse events in atopic dermatitis clinical trials
Drug efficacy is best evaluated by randomized, controlled, double-blind clinical trials; however, safety is harder to assess. The Medical Dictionary...
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Evaluation of Cardiac Adverse Events with Nivolumab Using a Japanese Real-World Database
BackgroundNivolumab has been used for the treatment of various types of cancers and has achieved improvements in overall survival. However, nivolumab...
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Hospital spending and length of stay attributable to perioperative adverse events for inpatient hip, knee, and spine surgery: a retrospective cohort study
BackgroundThe incremental hospital cost and length of stay (LOS) associated with adverse events (AEs) has not been well characterized for planned and...
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A Comprehensive Analysis of Reported Adverse Events and Device Failures Associated with Esophageal Self-Expandable Metal Stents: An FDA MAUDE Database Study
IntroductionEsophageal Stents are used to maintain esophageal lumen patency in esophageal strictures caused by intrinsic and/or extrinsic...
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Comparative Safety Surveillance of Triple (IDA) Versus Dual Therapy (DA) in Mass Drug Administration for Elimination of Lymphatic Filariasis in Kenya: A Cohort Event Monitoring Study
IntroductionDual diethylcarbamazine and albendazole (DA) therapy is the standard mass drug administration (MDA) regimen for lymphatic filariasis in...
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The psychological impact of adverse events on urology trainees
IntroductionAdverse events (AE) are an inevitable reality in healthcare, with an incidence of 7.5–14.1% worldwide. AEs are recognised to cause...
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Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis
BackgroundDrug repurposing refers to the application of existing drugs to new therapeutic indications. As phenotypic indicators of human drug...
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Frailty, gaps in care coordination, and preventable adverse events
BackgroundOlder US adults often receive care from multiple ambulatory providers. Seeing multiple providers may be clinically appropriate but creates...
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Adverse events of anti-IL-5 drugs in patients with eosinophilic asthma: a meta-analysis of randomized controlled trials and real-world evidence-based assessments
BackgroundWe aimed to clarify comprehensively the safety profiles of anti-IL-5 drugs and pinpoint potential safety concerns that may arise in their...
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Stress hyperglycemia ratio as a prognostic indicator for long-term adverse outcomes in heart failure with preserved ejection fraction
BackgroundRecent studies highlighted that stress hyperglycemia ratio (SHR) is a potential predictor for future risk in heart failure (HF) patients....
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Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan
IntroductionAdverse drug events (ADEs) are a major cause of mortality.
ObjectiveWe examined long-term trends for ADE-related deaths in Japan.
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