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Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions with increased BMI
Background/ObjectivesObesity has been ascribed to corticostriatal regions taking control over homeostatic areas. To test this assumption, we applied...
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The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis
Aims/hypothesis26RFa (pyroglutamilated RFamide peptide [QRFP]) is a biologically active peptide that regulates glucose homeostasis by acting as an...
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Non-Pharmacological Management of Insomnia Through Electrical Vestibular Stimulation (VeNS)
Purpose of ReviewInsomnia is a pathology characterized by the difficulty in initiating and maintaining sleep. It is a very prevalent disease...
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Hypothalamic subregion abnormalities are related to body mass index in patients with sporadic amyotrophic lateral sclerosis
ObjectiveTo investigate atrophy patterns in hypothalamic subunits at different stages of ALS and examine correlations between hypothalamic subunit...
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Impact of Fkbp5 × early life adversity × sex in humanised mice on multidimensional stress responses and circadian rhythmicity
The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes the prevalence of psychiatric disorders. Single...
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Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls
Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often...
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Neuroendocrinology of sexual behavior
One of the consequences of sexual behavior is reproduction. Thus, this behavior is essential for the survival of the species. However, the individual...
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Posterior hypothalamic involvement on pre-operative MRI predicts hypothalamic obesity in craniopharyngiomas
PurposeHypothalamic obesity (HO) is a complication associated with craniopharyngioma (CP). Attempts have been made to perioperatively predict the...
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Hypothalamic syndrome
Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-related injury to the hypothalamus, most commonly associated...
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Urocortin-3 neurons in the perifornical area are critical mediators of chronic stress on female infant-directed behavior
Infant avoidance and aggression are promoted by activation of the Urocortin-3 expressing neurons of the perifornical area of hypothalamus (PeFA Ucn3 )...
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Endoscopic endonasal approach to remove pediatric intraventricular tumors of the third ventricle
PurposePediatric intraventricular tumors of the third ventricle are among the most difficult-to-treat brain tumors. Recently, endonasal endoscopic...
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Evaluation of Orexin-A Salivary Levels and its Correlation with Attention After Non-invasive Brain Stimulation in Female Volleyball Players
BackgroundThe capacity to change attention from one area to another depending on the many environmental circumstances present is a crucial aspect of...
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Arterial spin labeling MRI applied to migraine: current insights and future perspectives
IntroductionAdvanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of...
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Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial
BackgroundObesity is a disease that may involve disrupted connectivity of brain networks. Bariatric surgery is an effective treatment for obesity,...
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Gene expression analyses on multi-target mode of action of black cohosh in menopausal complaints – a pilot study in rodents
PurposeThis study aimed at assessing gene expression profiles in hippocampus and hypothalamus of ovariectomized (OVX) rats with or without treatment...
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Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion
Hyperhidrosis (HH) is a central nervous dysfunction characterized by abnormally increased sweating due to a central dysregulation of sweat secretion....
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Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Depression is a mental illness frequently accompanied by disordered energy metabolism. A dysregulated hypothalamus pituitary adrenal axis response...
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Neurochemical and Hormonal Contributors to Compulsive Sexual Behavior Disorder
Purpose of ReviewCompulsive sexual behavior disorder has been recently included in the 11th revision of the International Classification of Diseases...
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Polycystic ovary rat model exposure to 150 kHz intermediate frequency: hypothalamic-pituitary-ovarian axis at the receptor, cellular, tissue, and hormone levels
IntroductionThe hypothalamic-pituitary-ovarian (HPO) axis is the principal regulator of the reproductive system. The neurons in the arcuate nucleus...
