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Acute liver failure in Still’s disease relapse during pregnancy: case report and discussion of a possible trigger role of DILI
BackgroundStill's disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement. The most common cause of acute...
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The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study
BackgroundGilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt....
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Neonatal Jaundice
Hyperbilirubinemia is a common occurrence in neonates; it may be physiological or pathological. Conjugated hyperbilirubinemia may result from medical...
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Association between total bilirubin and bone mineral density level in adolescents
BackgroundIncreasing bone mass accumulation in adolescence and obtaining greater peak bone mass is one of the effective methods to prevent...
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A unique case of black choledocholithiasis: a video-based case review in the Pancreato-Biliary Division–Endoscopy Unit of National Liver Institute (NLI)
BackgroundBlack gall stones are consistently described in relation to haem turnover and hemolytic disorders. Black gall stones are also a frequent...
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High unbound bilirubin for age: a neurotoxin with major effects on the develo** brain
Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin...
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Association of placental histology and neonatal hematologic outcomes
ObjectiveThe objective of the paper was to investigate how neonatal hematologic outcomes vary by major placental histopathology categories.
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Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
BackgroundAnti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma, yet their...
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Safety and Effectiveness of Rasburicase in the Control of Hyperuricemia in Pediatric Patients with Non-Hodgkin’s Lymphoma and Acute Leukemia: An Open-Label, Single-Arm, Multi-center, Interventional Study
IntroductionDespite rasburicase's proven efficiency in Caucasians, Japanese, and Koreans, studies evaluating the safety and effectiveness of...
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Case report: multiple UGT1A1 gene variants in a patient with Crigler-Najjar syndrome
BackgroundInherited unconjugated hyperbilirubinemia is caused by variants in the gene UGT1A1 leading to Gilbert’s syndrome and Crigler-Najjar...
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Frequency, pattern, and associations of renal iron accumulation in sickle/β-thalassemia patients
We evaluated frequency, pattern, and associations of renal iron accumulation in sickle/β-thalassemia. Thirty-three sickle/β-thalassemia patients...
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Bilirubin as an indicator of cardiometabolic health: a cross-sectional analysis in the UK Biobank
BackgroundMildly elevated bilirubin, a by-product of hemoglobin breakdown, might mitigate cardiometabolic risk factors including adiposity,...
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Impact of preterm birth and low birth weight on medical conditions, medication use and mortality among neonates: a prospective observational cohort study
BackgroundThere is a paucity of studies conducted in India on neonatal outcomes of preterm birth and low birth weight. Hence, we aimed to assess the...
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Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study
BackgroundThis study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population.
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Interactions between nuclear receptors glucocorticoid receptor α and peroxisome proliferator–activated receptor α form a negative feedback loop
Both nuclear receptors glucocorticoid receptor α (GRα) and peroxisome proliferator–activated receptor α (PPARα) are involved in energy and lipid...
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Hemolysis during open heart surgery in patients with hereditary spherocytosis — systematic review of the literature and case study
BackgroundDue to the distinctive nature of cardiac surgery, patients suffering from hereditary spherocytosis (HS) are potentially at a high risk of...
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