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1. Brivaracetam Retention Rate and Seizure Outcomes in Patients with Drug-Resistant Focal Epilepsy Included in the Medical Need Program in Belgium: A Real-World, Multicenter, Chart Review

   Background

   New treatments are needed for patients with drug-resistant epilepsy to improve seizure control without decreasing quality of life.

   ...

   Chantal Depondt, Wim Van Paesschen, ... France Ferrière in Drugs - Real World Outcomes

   Article Open access 31 May 2021
   

2. Targeting the molecular web of Alzheimer’s disease: unveiling pathways for effective pharmacotherapy

   Introduction

   Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with...

   Devika Jadhav, Nikita Saraswat, ... Devendra Shirode in The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

   Article Open access 11 January 2024
   

3. Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)

   Background

   In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy....

   Simona Lattanzi, Laura Canafoglia, ... Lelia Zummo in CNS Drugs

   Article Open access 02 September 2021
   

4. Efficacy and Safety of Levetiracetam on the Treatment of Spasticity in Neurologic Disorders: a Systematic Review

   Spasticity is one of the disabling complications of various neurologic disorders. Its relief through available pharmacotherapy is oftentimes...

   Jane Marice S. Pascual, Karen Joy B. Adiao, Mario B. Prado Jr in SN Comprehensive Clinical Medicine

   Article 23 August 2023
   

5. Neurogenesis-independent mechanisms of MRI-detectable hippocampal volume increase following electroconvulsive stimulation

   Electroconvulsive therapy (ECT) is one of the most effective psychiatric treatments but the underlying mechanisms are still unclear. In vivo human...

   Yoshifumi Abe, Kiichi Yokoyama, ... Akihiro Takamiya in Neuropsychopharmacology

   Article Open access 09 January 2024
   

6. Historical and current issues in HIV encephalitis, and the role of neuropathology in HIV disease: a pathological perspective

   In the 1980s, after the HIV pandemic was recognised, neuropathology identified cerebral white matter lesions that were found in the brains of...

   Sebastian Lucas in Journal of Neurology

   Article Open access 02 December 2022
   

7. The Leuven late life depression (L3D) study: PET-MRI biomarkers of pathological brain ageing in late-life depression: study protocol

   Background

   Major depressive disorders rank in the top ten causes of ill health in all but four countries worldwide and are the leading cause of years...

   Louise Emsell, Maarten Laroy, ... Mathieu Vandenbulcke in BMC Psychiatry

   Article Open access 28 January 2021
   

8. Effect of Levetiracetam on Cognition: A Systematic Review and Meta-analysis of Double-Blind Randomized Placebo-Controlled Trials

   Background

   Studies have suggested that levetiracetam may help improve cognitive function in patients with epilepsy. Recently, its efficacy in...

   Chia-Yen Lin, Meng-Chia Chang, Hong-Jie Jhou in CNS Drugs

   Article 15 December 2023
   

9. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism

   Mutations in many synaptic genes are associated with autism spectrum disorders (ASD), suggesting that synaptic dysfunction is a key driver of ASD...

   Le Wang, Vincent R. Mirabella, ... Zhi** P. Pang in Molecular Psychiatry

   Article 24 October 2022
   

10. Predictive factors for post operative seizures following meningioma resection in patients without preoperative seizures: a multicenter retrospective analysis

    Purpose

    Meningiomas are the most common primary brain tumor and represent 35% of all intracranial neoplasms. However, in the early post-operative...

    Chase McKevitt, Lina Marenco-Hillembrand, ... Kaisorn L. Chaichana in Acta Neurochirurgica

    Article 28 March 2023
    

11. Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A Retrospective, Multicenter, Real-World Study

    Introduction

    In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Most...

    Simona Lattanzi, Laura Canafoglia, ... Lelia Zummo in Neurology and Therapy

    Article Open access 16 September 2022
    

12. PET imaging of animal models with depressive-like phenotypes

    Major depressive disorder is a growing and poorly understood pathology. Due to technical and ethical limitations, a significant proportion of the...

    Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, ... Janine Doorduin in European Journal of Nuclear Medicine and Molecular Imaging

    Article Open access 16 January 2023

13. Quantification of [¹⁸F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value

    Purpose

    [ ¹⁸ F]UCB-H is a specific positron emission tomography (PET) biomarker for the Synaptic Vesicle protein 2A (SV2A), the binding site of the...

    Maria Elisa Serrano, Mohamed Ali Bahri, ... Alain Plenevaux in Molecular Imaging and Biology

    Article 20 November 2018
    

14. Biomarkers for Alzheimer’s disease—preparing for a new era of disease-modifying therapies

    Clinical trial results presented in 2019 suggest that antibody-based removal of cerebral amyloid β (Aβ) plaques may possibly clear tau tangles and...

    Henrik Zetterberg, Barbara B. Bendlin in Molecular Psychiatry

    Article 06 April 2020
    

15. Validation of Parametric Methods for [¹¹C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue

    Purpose

    The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([ ¹¹ C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifl...

    Nathalie Mertens, Ralph Paul Maguire, ... Michel Koole in Molecular Imaging and Biology

    Article 17 June 2019
    

16. Efficacy of rTMS for poststroke epilepsy and its effects on patients’ cognitive function and depressive status

    Objective

    This study aimed to investigate the efficacy of rTMS in the treatment of poststroke epilepsy and the effect of rTMS on patients’ cognitive...

    Minting Hu, Bailing Qin, ... Zuocai Tan in BMC Neurology

    Article Open access 12 January 2024
    

17. Towards an understanding of psychedelic-induced neuroplasticity

    Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and...

    Abigail E. Calder, Gregor Hasler in Neuropsychopharmacology

    Article Open access 19 September 2022
    

18. The Toxicity of Newer and Lesser-Known Anticonvulsant Drugs

    Purpose of Review

    This review describes newer and lesser-known anticonvulsant drugs. Due to increased diagnostic accuracy of seizure disorder...

    Steven J. Walsh, Richard J. Chen, ... James A. Krueger in Current Emergency and Hospital Medicine Reports

    Article 22 August 2020

19. Altersepilepsie

    Epilepsy is the third most frequent neurological disorder in aged patients after stroke and dementia. The incidence of epilepsy increases with age...

    Alexandra Rohracher, Eugen Trinka in Zeitschrift für Gerontologie und Geriatrie

    Article Open access 23 April 2021
    

20. Pharmakotherapie und intensivmedizinische Aspekte des Status epilepticus: Update 2020/2021

    Focused treatment of epileptic emergencies, and in particular status epilepticus (SE), require a reliable differentiation of epileptic syndromes. In...

    Gabrielė Saitov, Annekatrin Müller, ... Dominik Michalski in Der Anaesthesist

    Article Open access 01 July 2021