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Procollagen C-proteinase enhancer-1 and renal failure in multiple myeloma
BackgroundRenal involvement is present in approximately 50% of multiple myeloma (MM) cases and is associated with a poor prognosis. Procollagen...
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Real-world outcome of patients with extensively pretreated multiple myeloma who were treated with selinexor and dexamethasone: a Korean multicenter retrospective analysis
The outcomes of patients with myeloma after exposed to penta-classes are extremely poor. Selinexor is the first approved exportin inhibitor for those...
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Bispecific CS1-BCMA CAR-T cells are clinically active in relapsed or refractory multiple myeloma
Multiple myeloma (MM) bears heterogeneous cells that poses a challenge for single-target immunotherapies. Here we constructed bispecific CS1-BCMA...
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The impact of social vulnerability index on survival following autologous stem cell transplant for multiple myeloma
Autologous hematopoietic stem cell transplantation (ASCT) is the standard of care for eligible patients with multiple myeloma (MM) to prolong...
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The unknown impact of multiple myeloma: assessing the impact of financial well-being on quality of life of caregivers
PurposePatients with multiple myeloma and their caregivers are financially burdened, and their quality of life is significantly affected by treatment...
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Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
Trace elements are essential micronutrients for the human body. Their roles are indispensable, as they are involved in a wide range of vital...
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Thrombosis events in Chinese patients with newly diagnosed multiple myeloma
A high risk of thrombosis is seen in patients with newly diagnosed multiple myeloma (NDMM), particularly those treated with immunomodulatory drugs...
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Recent trends in incidence, survival and treatment of multiple myeloma in Finland – a nationwide cohort study
This study aimed to determine the incidence and prevalence of multiple myeloma (MM) in Finland in 2015–2019, to characterize adult patients newly...
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Immune dysregulation in multiple myeloma: the current and future role of cell-based immunotherapy
Immune dysregulation is a hallmark of clinically active multiple myeloma (MM). Interactions between malignant clonal cells and immune cells within...
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Immunophenotypic profile defines cytogenetic stability and unveils distinct prognoses in patients with newly-diagnosed multiple myeloma (NDMM)
Prognostic significance of multiple immune antigens in multiple myeloma has been well established. However, a level of uncertainty remains regarding...
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Acute kidney injury in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant: a cohort study
BackgroundAutologous hematopoietic stem cell transplant plays an important role in multiple myeloma (MM) treatment. Increasing incidence of MM and...
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Semi-quantitative FDG parameters predict survival in multiple myeloma patients without autologous stem cell transplantation
BackgroundF-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is useful in multiple myeloma (MM) for initial workup...
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Immunotherapies targeting GPRC5D in relapsed or refractory multiple myeloma: latest updates from 2022 ASH Annual Meeting
B cell maturation antigen (BCMA)-targeted immunotherapy has shown unprecedented results in the treatment of relapsed or refractory (R/R) multiple...
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Lumbar MR-based radiomics nomogram for detecting minimal residual disease in patients with multiple myeloma
ObjectivesMinimal residual disease (MRD) is a standard for assessing treatment response in multiple myeloma (MM). MRD negativity is considered to be...
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Population Pharmacokinetics and Exposure–Response with Teclistamab in Patients With Relapsed/Refractory Multiple Myeloma: Results From MajesTEC-1
BackgroundTeclistamab, a B-cell maturation antigen × CD3 bispecific antibody, is approved in patients with relapsed/refractory multiple myeloma...
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Clinical Features and Outcomes of Patients with Double-Hit/Triple-Hit Multiple Myeloma Detected at Relapse
IntroductionmSMART classifies high-risk Multiple Myeloma patients into Double Hit and Triple Hit Myeloma (DH/THM) on the basis of the number of...
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Novel methyltransferase G9a inhibitor induces ferroptosis in multiple myeloma through Nrf2/HO-1 pathway
Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development and drug...
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Dismal prognosis of Pneumocystis jirovecii pneumonia in patients with multiple myeloma
Patients with multiple myeloma (MM) are at high risk for infections, including opportunistic infections such as Pneumocystis jirovecii pneumonia...
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A gene signature can predict risk of MGUS progressing to multiple myeloma
Multiple myeloma is preceded by monoclonal gammopathy of undetermined significance (MGUS). Serum markers are currently used to stratify MGUS patients...
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Pharmacodynamic-Mediated Drug Disposition (PDMDD) Model of Daratumumab Monotherapy in Patients with Multiple Myeloma
Background and ObjectiveWe aimed to quantify the daratumumab concentration- and CD38 dynamics-dependent pharmacokinetics using a pharmacodynamic...