Search
Search Results
-
Long noncoding RNA CRCMSL suppresses tumor invasive and metastasis in colorectal carcinoma through nucleocytoplasmic shuttling of HMGB2
AbstractLong noncoding RNAs (lncRNAs) are pervasive transcripts that play pivotal roles in regulating chromatin dynamics, gene and protein...
-
Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral tumor of female children with a good prognosis that is distinct from classical astroblastoma
PurposeReview of the clinicopathologic and genetic features of early ependymal tumor with MN1-BEND2 fusion (EET MN1-BEND2), classical...
-
Predictive biomarkers for the early detection and management of heart failure
Cardiovascular disease (CVD) is a serious public health concern whose incidence has been on a rise and is projected by the World Health Organization...
-
KCNQ1OT1 promotes retinoblastoma progression by targeting miR-339-3p that suppresses KIF23
BackgroundLong noncoding RNAs (lncRNAs) are involved in tumor formation and development. KCNQ1OT1 regulates the malignant proliferation of...
-
MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics
The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic and preventative strategies to attenuate complications of...
-
Strategies to target long non-coding RNAs in cancer treatment: progress and challenges
BackgroundLong non-coding RNAs are important regulators of gene expression and diverse biological processes. Their aberrant expression contributes to...
-
LncRNA MACC1-AS1 sponges multiple miRNAs and RNA-binding protein PTBP1
Long noncoding RNA (lncRNA) represents a class of endogenous RNAs that regulate gene expression in eukaryotes. To date, the function and underlying...
-
Exosomes: key players in cancer and potential therapeutic strategy
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes,...
-
Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer
BackgroundThe altered long non-coding RNA (lncRNA), circular RNA (circRNA) and mRNA expression in triple-negative breast cancer (TNBC) after...
-
Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer
BackgroundCompelling studies have demonstrated the correlation between aberrant expressed lncRNAs and human cancers, and revealed promise of these...
-
LINC01433 targets miR-506-3p to promote the biological progress of nasopharyngeal carcinoma cells
PurposeThe current study aimed to investigate the role of long intergenic noncoding 01433 (LINC01433) in the proliferation, migration and invasion of...
-
TERRA Gene Expression in Gastric Cancer: Role of hTERT
PurposeOne of the most important serious malignancies is gastric cancer (GC) with a high mortality globally. In this way, beside the environmental...
-
The anti-aging role of metformin, clinical applications to pursue the longevity road
BackgroundMetformin, an oral antidiabetic drug widely used for over 60 years, has been recognized for its safety and effectiveness in the treatment...
-
Prognostic utility of lncRNAs (LINC00565 and LINC00641) as molecular markers in glioblastoma multiforme (GBM)
Background and aimGlioblastoma multiforme (GBM) is primary brain tumor grade IV characterized by fast cell proliferation, high mortality and...
-
New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. It is essential to develop novel interventions to...
-
MALAT1: a therapeutic candidate for a broad spectrum of vascular and cardiorenal complications
Cardiovascular and renal complications cover a wide array of diseases. The most commonly known overlap** complications include cardiac and renal...
-
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity,...
-
Noncoding RNAs in cancer therapy resistance and targeted drug development
Noncoding RNAs (ncRNAs) represent a large segment of the human transcriptome and have been shown to play important roles in cellular physiology and...
-
A critical approach for successful use of circulating microRNAs as biomarkers in cardiovascular diseases: the case of hypertrophic cardiomyopathy
MicroRNAs (miRNAs) are small noncoding RNA molecules that act as major regulators of gene expression at the post-transcriptional level. As the...
-
PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression
BackgroundEndometriosis, a common gynaecological disease in women, affects 10% of women of childbearing age. Among infertile women, this proportion...
