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The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial
BackgroundCOVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological...
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Effects of Hormone Replacement Therapy on Women's Lung Health and Disease
This review provides an overview of menopausal hormone therapy and pulmonary disease risk, with a focus on the effect of hormone replacement therapy...
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Role of macrophage-to-myofibroblast transition in chronic liver injury and liver fibrosis
BackgroundChronic liver injury contributes to liver fibrosis, which is characterized by the excessive deposition of extracellular matrix (ECM)...
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Trastuzumab Deruxtecan-Induced Interstitial Lung Disease/Pneumonitis in ERBB2-Positive Advanced Solid Malignancies: A Systematic Review
Background and ObjectiveTrastuzumab deruxtecan (T-DXd) is a novel anti-ERBB2 antibody drug conjugate that appears to be associated with an increased...
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Systemic sclerosis interstitial lung disease: unmet needs and potential solutions
Systemic sclerosis (SSc), or scleroderma, is a rare, complex, systemic autoimmune disease of unknown aetiology, characterized by high morbidity and...
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Why Cell-Free DNA Can Be a “Game Changer” for Lung Allograft Monitoring for Rejection and Infection
Purpose of ReviewAlthough there has been improvement in short-term clinical outcomes for patients following lung transplant (LT), advances have not...
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A role of STING signaling in obesity-induced lung inflammation
BackgroundIt is established that pulmonary disorders are comorbid with metabolic disorders such as obesity. Previous studies show that the stimulator...
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Anesthesia for lung transplantation in children under 12 years of age: a single center experience of China
PurposeThis study aims to provide a comprehensive overview of anesthesia management strategies employed in pediatric lung transplantation.
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A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
BackgroundSystemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the...
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Differences in clinical characteristics and liver injury between patients diagnosed with the Omicron subvariant BA.5.2 and the prototype of SARS-CoV-2: a single center retrospective study
BackgroundThe purpose of this study was to investigate the differences between the clinical characteristics and the factors influencing liver injury...
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...
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Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib
Background and objectiveSystemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by fibrosis and vascular lesions. Interstitial...
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Roles of airway basal stem cells in lung homeostasis and regenerative medicine
Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to...
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Antifibrotic mechanism of avitinib in bleomycin-induced pulmonary fibrosis in mice
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by alveolar epithelial cell injury and lung...
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Lung cancer in the emergency department
BackgroundThough decreasing in incidence and mortality in the USA, lung cancer remains the deadliest of all cancers. For a significant number of...
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Plumbagin attenuates Bleomycin-induced lung fibrosis in mice
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with limited treatment options. Plumbagin (PL) is an herbal extract...
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An unusual form of kidney injury without glomerulonephritis in microscopic polyangiitis: a case report
BackgroundMicroscopic polyangiitis (MPA), a kind of antineutrophil cytoplasmic autoantibody associated vasculitis (AAV), predominantly affects...
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Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach
Xuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been widely used to treat a variety of respiratory diseases...
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Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection
BackgroundAberrant Wnt5a expression contributes to immunity, inflammation and tissue damage. However, it remains unknown whether Wnt5a is associated...
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Basiliximab for early perioperative transplant-associated thrombotic microangiopathy after lung transplantation: a case report
BackgroundThrombotic microangiopathy is a syndrome characterized by microangiopathic hemolytic anemia and platelet aggregation, which is caused by...
