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Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats
BackgroundIn children, recombinant human growth hormone (rhGH) therapy for treatment of short stature has raised concerns of the early onset of...
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PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans
PurposeToludesvenlafaxine is a recently developed antidepressant that belongs to the triple reuptake inhibitor class. Despite the in vitro evidence...
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Classical music restored fertility status in rat model of premature ovarian failure
Background:The restorative effect of classical music was assessed on the cyclophosphamide-induced animal model of premature ovarian failure (POF).
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Central stress pathways in the development of cardiovascular disease
PurposeMental stress is of essential consideration when assessing cardiovascular pathophysiology in all patient populations. Substantial evidence...
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Low-dose ACTH test for evaluation of hypothalamus–pituitary–adrenal axis preoperatively and 3-month follow-up in non-functioning pituitary adenomas
BackgroundPeri-operative glucocorticoids are routinely administered to patients undergoing trans-sphenoidal surgery for non-functional pituitary...
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Decreased levels of hydrogen sulfide in the hypothalamic paraventricular nucleus contribute to sympathetic hyperactivity induced by cerebral infarction
Paroxysmal sympathetic hyperactivity (PSH) is a common clinical feature secondary to ischemic stroke (IS), but its mechanism is poorly understood. We...
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Effect of scan-time shortening on the 11C-PHNO binding potential to dopamine D3 receptor in humans and test–retest reliability
Objective11 C-PHNO is a PET radioligand most specific to dopamine D 3 receptor (D 3 R). The long scan duration of 120 min used in quantification of 11 C-P...
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Expanded endoscopic endonasal approach for the resection of midline craniopharyngiomas with hypothalamic involvement
BackgroundWith relevant surrounding neurological structures and potential involvement of the hypothalamus, the surgical management of...
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Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling: relevance to aggressive behavior in humans
Oxytocin is a neuropeptide produced mainly in the hypothalamus and secreted in the CNS and blood. In the brain, it plays a major role in promoting...
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Selective surgical mamillo-thalamic tract disconnection in hypothalamic hamartoma results in complete disappearance of gelastic seizures
Hypothalamic hamartoma is a less common condition characterized by the several types of epileptic seizures including the gelastic type. It is...
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Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3 immunoreactivity
PurposePolycystic ovary syndrome (PCOS) is a complex reproductive event that is delineated by endocrine/metabolic disorders. Alteration of kisspeptin...
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Enriched biscuits of Ficus Capensis modulates neurobehavioral performance and antioxidant status of L-NAME-induced hypertensive rats with anxiety-like behavior
PurposeAnxiety and cognitive deterioration in hypertensive patients are underreported especially in hypertensive state. This study investigated the...
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Brain proteomic atlas of alcohol use disorder in adult males
Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs, including the brain. There has not been a...
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Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
BackgroundDespite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, the inconsistencies of previous...
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Study on reverse transsynaptic virus tracing targeting Shenmen (HT7) and heart in mice
ObjectiveTo investigate the neural connections between Shenmen (HT7)-heart and the brain by observing the tracing viruses co-labeled brain nuclear...
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Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study
BackgroundResearch on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in...
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Antipsychotics impair regulation of glucose metabolism by central glucose
Hypothalamic detection of elevated circulating glucose triggers suppression of endogenous glucose production (EGP) to maintain glucose homeostasis....
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Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine
BackgroundMigraine, a complex brain disorder, is regarded as a possible clinical manifestation of brain energy dysfunction. The trigeminovascular...
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Pathophysiologie der Adipositas
Obesity is a chronic, progressive, incurable disease that is frequently characterized by relapse after short-term interventions. Through increased...
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Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
BackgroundThe premonitory phase, or prodrome, of migraine, provides valuable opportunities to study attack initiation and for treating the attack...
