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Spectrum of Liver: GI Disorders in Pregnancy
Pregnant women are affected by gastrointestinal and liver disorders. These may or may not be related to pregnancy. Unrelated conditions are...
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Care of Infants Born to Women with Diabetes
Purpose of ReviewInfants of women with diabetes are at risk for specific morbidities including congenital anomalies, abnormalities of fetal growth,...
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Mechanisms of pruritus in cholestasis: understanding and treating the itch
Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the quality of life of those affected. Here, we provide an...
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Confounding factors in the diagnosis and clinical course of rare congenital hemolytic anemias
Congenital hemolytic anemias (CHAs) comprise defects of the erythrocyte membrane proteins and of red blood cell enzymes metabolism, along with...
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Ensemble learning for the early prediction of neonatal jaundice with genetic features
BackgroundNeonatal jaundice may cause severe neurological damage if poorly evaluated and diagnosed when high bilirubin occurs. The study explored how...
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Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
BackgroundBilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary...
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Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
IntroductionBAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology of...
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LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats
BackgroundPhototherapy (PT) is the standard treatment of neonatal unconjugated hyperbilirubinemia. Fluorescent tube (FT)-emitted PT light is known to...
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Serum Calcium and Melatonin Levels in Neonates Undergoing Phototherapy
Phototherapy-induced hypocalcemia has been postulated to result from a decline in serum melatonin levels. The present observational study evaluated...
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Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia
Extracorporeal membrane oxygenation (ECMO) is an emerging tool for supporting cardiopulmonary function in patients with cardiorespiratory failure or...
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Detecting acute bilirubin encephalopathy in neonates based on multimodal MRI with deep learning
BackgroundDifferentiating acute bilirubin encephalopathy (ABE) from non-ABE in neonates with hyperbilirubinemia (HB) from routine magnetic resonance...
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Clofibrate as an Adjunct to Phototherapy for Unconjugated Hyperbilirubinemia in Term Neonates
ObjectiveTo evaluate the efficacy of oral clofibrate as an adjunct to phototherapy for unconjugated hyperbilirubinemia in term neonates.
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Experimental models assessing bilirubin neurotoxicity
The molecular and cellular events leading to bilirubin-induced neurotoxicity, the mechanisms regulating liver and intestine expression in neonates,...
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Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons
BackgroundBilirubin encephalopathy, the most serious complication of hyperbilirubinemia during the neonatal period, with high mortality and...
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Liver and Tropical Infections
Purpose of ReviewTropical infections may present with primary hepatobiliary manifestations mimicking other liver diseases. Gastroenterologists and...
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Hyperthyroxinemia at birth: a cause of idiopathic neonatal hyperbilirubinemia?
BackgroundSome neonates develop idiopathic hyperbilirubinemia (INHB) requiring phototherapy, yet with no identifiable causes. We searched for an...
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Sustained lower bilirubin-binding affinity of albumin in extremely preterm infants
BackgroundElevated albumin-free or unbound bilirubin (UB) levels beyond the first week of life have been associated with the development of bilirubin...
