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Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment
Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of...
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Lymphocyte–C-reactive protein ratio as a prognostic marker associated with the tumor immune microenvironment in intrahepatic cholangiocarcinoma
BackgroundChanges in immune cell and inflammation-associated protein levels, either independently or in combination, are commonly used as prognostic...
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Establishment and validation of an aging-related risk signature associated with prognosis and tumor immune microenvironment in breast cancer
BackgroundBreast cancer (BC) is a highly malignant and heterogeneous tumor which is currently the cancer with the highest incidence and seriously...
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Role of Automated Volume, Conductivity and Scatter (VCS) Parameters of Neutrophils as Indicators of Sepsis
This study was done to evaluate the role of automated volume, conductivity and scatter (VCS) parameters of neutrophils as indicators of sepsis and...
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CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model
The immune microenvironment of tumors can play a critical role in promoting or inhibiting tumor progression depending on the context. We present...
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Synovial fluid neutrophils in oligoarticular juvenile idiopathic arthritis have an altered phenotype and impaired effector functions
BackgroundNeutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile...
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CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils
Deregulated expression of chemokines in tumor microenvironment contributes to tumor metastasis by targeting distinct cells. Epithelial-derived...
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Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data
Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic...
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A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis
Tumor-associated macrophages (TAMs) are abundant in tumors and interact with tumor cells, leading to the formation of an immunosuppressive...
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Heterotypic clustering of circulating tumor cells and circulating cancer-associated fibroblasts facilitates breast cancer metastasis
BackgroundCancer-associated fibroblasts (CAFs) are recruited to the tumor microenvironment (TME) and are critical drivers of breast cancer (BC)...
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NETs: an extracellular DNA network structure with implication for cardiovascular disease and cancer
Cardiovascular (CV) diseases and tumors are best known for its high morbidity and mortality worldwide. There is a growing recognition of the...
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Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis
Purpose of ReviewSince obesity is a major risk factor for many different types of cancer, examining one of the most closely associated comorbidities,...
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A novel CD47-blocking peptide fused to pro-apoptotic KLA repeat inhibits lung cancer growth in mice
CD47 is highly expressed in many tumor tissues and induces immune evasion by interaction with SIRP-alpha (signal regulatory protein-alpha) expressed...
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A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment
Stimulator of interferon genes (STING) contributes to anti-tumor immunity by activating antigen-presenting cells and inducing mobilization of...
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GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant
Antibody responses to off-target cancer-associated proteins have been detected following immunotherapies for cancer, suggesting these may be the...
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Research progress of tumor microenvironment and tumor-associated macrophages
Cancer is a health issue causing utmost concern and continuing to be one of the leading causes of mortality worldwide. Effective tumor eradication...
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Overexpressed pseudogene MT1L associated with tumor immune infiltrates and indicates a worse prognosis in BLCA
BackgroundBLCA is a common cancer worldwide, and it is both aggressive and fatal. Immunotherapy (ICT) has achieved an excellent curative effect in...
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Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire
Systemic rheumatic diseases are a heterogeneous group of disorders characterized by profound immune dysregulation. Recent discoveries have led to a...
