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Comparison of the effects of the l-dopa and insulin tolerance tests on cortisol secretion
PurposeThe aims of the present study are to evaluate the effect of l -dopa on the secretion of cortisol and adrenocorticotropic hormone (ACTH) in...
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Cognitive disorders in advanced Parkinson’s disease: challenges in the diagnosis of delirium
Parkinson’s disease (PD) is a neurodegenerative condition that is frequently associated with cognitive disorders. These can arise directly from the...
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The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson’s Disease
IntroductionEthnicity differences are an important determinant in the clinical manifestation of Parkinson’s disease (PD), but they are not yet widely...
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Signal transduction in l-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression
A large number of signaling abnormalities have been implicated in the emergence and expression of l -DOPA-induced dyskinesia (LID). The primary cause...
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Brainstem cavernous hemangioma with improvement of Holmes tremor on excision
An 8-year-old boy presenting with left-angle paralysis, tremor in upper and lower extremities, and diplopia was diagnosed with hemorrhage from a...
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Screening for Fabry disease in a series of Parkinson’s disease patients and literature review
BackgroundSo far, mutations in genes encoding lysosomal enzymes have been associated with Parkinson’s disease (PD). Fabry disease (FD) is an X-linked...
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The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson’s Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On
In the 1980s, Orion Pharma, then a mid-ranking Nordic area pharmaceutical company, established a drug development programme on the inhibition of...
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Fokus atypische Parkinsonsyndrome: Teil 1 – Multisystematrophie
Multisystem atrophy is a neurodegenerative disorder belonging to the atypical Parkinsonian syndromes and is rare with an incidence of 5/100,000. It...
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The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine...
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The XINDI Study: A Randomized Phase III Clinical Trial Evaluating the Efficacy and Safety of Safinamide as Add-On Therapy to Levodopa in Chinese Patients with Parkinson’s Disease with Motor Fluctuations
BackgroundLevodopa remains the gold standard for the treatment of Parkinson’s disease, but its long-term use is associated with motor complications...
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Is 18F-DOPA a valid cardiac sympathetic neuroimaging agent?
Purpose18 F-Dopamine positron emission tomography is a validated method for identifying cardiac noradrenergic deficiency, a characteristic feature of...
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Sex-related differences in the clinical presentation of multiple system atrophy
PurposeTo investigate sex-related differences in the clinical presentation of multiple system atrophy (MSA) through a literature review and an...
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Glutamatergic mechanisms in l-DOPA-induced dyskinesia and therapeutic implications
Overactivation of the glutamatergic synapse leading to maladaptive synaptic plasticity in the basal ganglia is a well-demonstrated process involved...
