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First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers
BackgroundIMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has...
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Weight cycling based on altered immune microenvironment as a result of metaflammation
As a result of the obesity epidemic, more people are concerned about losing weight; however, weight regain is common, leading to repeated weight loss...
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Cellular Alterations in Immune Checkpoint Inhibitor Therapy-Related Cardiac Dysfunction
Purpose of ReviewImmune checkpoint inhibitor (ICI) therapy has emerged as a pivotal advancement in cancer treatment, but the widespread adoption has...
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Update on Immune Checkpoint Inhibitor Enterocolitis
Purpose of ReviewImmune checkpoint inhibitor (ICI) therapy revolutionized the treatment of multiple solid and hematologic malignancies. Yet, with it...
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Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma
BackgroundsThe overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can...
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Mitral valve replacement in patients of rheumatic heart disease associated with immune thrombocytopenia
Immune thrombocytopenia in association with rheumatic heart disease is not commonly seen. Surgical management of rheumatic heart disease becomes more...
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Immune checkpoint inhibitor-induced hypophysitis: clinical and biochemical features
Immune checkpoint inhibitors are a very promising novel class of immune response-regulating drugs for cancer treatment. Hypophysitis is one of their...
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Severe neuromuscular immune-related adverse events of immune checkpoint inhibitors at national cancer center in Korea
PurposeNeuromuscular immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs) have been increasingly recognized as a...
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Immune-related adverse events after immune checkpoint inhibitor exposure in adult cancer patients with pre-existing autoimmune diseases
PurposeImmune checkpoint inhibitor (ICI) therapy can predispose patients to immune-related adverse events (irAEs) and autoimmune disease (AD)...
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Immune checkpoint inhibitor-related type 1 diabetes mellitus which develops long after treatment discontinuation: a case report and review of literature
Immune checkpoint inhibitor (ICI)-related type 1 diabetes is an immune-related adverse event (irAE), occurring in slightly less than 1% of patients...
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Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of chronic pain...
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Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway
ObjectiveTo explore the anti-tumor effect of safflower yellow (SY) against hepatocellular carcinoma (HCC) and the underlying potential mechanism.
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Cardiovascular Effects of Immune Checkpoint Inhibitors: More Than Just Myocarditis
Purpose of ReviewImmune checkpoint inhibitors have reshaped the treatment of cancer, but they are characterized by peculiar toxicity consisting of...
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The kinetics of inhibitory immune checkpoints during and post-COVID-19: the knowns and unknowns
The immune system is tightly regulated to prevent immune reactions to self-antigens and to avoid excessive immune responses during and after...
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Tumor immune microenvironment and clinical outcomes in stage IV urothelial cancer: YODO study
BackgroundBladder cancer is the 10th most common cancer globally, with a growing incidence in Japan. Evaluation of molecular, genetic, and cellular...
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Associations between HIFs and tumor immune checkpoints: mechanism and therapy
Hypoxia, which activates a variety of signaling pathways to enhance tumor cell growth and metabolism, is among the primary features of tumor cells....
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Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis
BackgroundPulmonary fibrosis (PF) represents the pathologic end stage of several interstitial lung diseases (ILDs) associated with high morbidity and...
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The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation
The effects of irradiation on tumor tissue and the host immune system are interrelated. The antitumor effect of irradiation is attenuated in the...
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Prognostic and onco-immunological value of immune-related eRNAs-driven genes in lung adenocarcinoma
BackgroundWe aimed to comprehensively analyze the clinical value of immune-related eRNAs-driven genes in lung adenocarcinoma (LUAD) and find the...
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Exploring the frontiers: tumor immune microenvironment and immunotherapy in head and neck squamous cell carcinoma
The global prevalence of head and neck malignancies positions them as the sixth most common form of cancer, with the head and neck squamous cell...
