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Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some...
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Management of NAFLD: a stage-based approach
NAFLD is the most prevalent form of liver disease in the USA, affecting an estimated 30% of the population. The condition is associated with...
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Bile acids: emerging role in management of liver diseases
Bile acids are well known for their effects on cholesterol homeostasis and lipid digestion. Since the discovery of bile acid receptors, of which...
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The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans
Nonalcoholic fatty liver disease (NAFLD) describes steatosis, nonalcoholic steatohepatitis with or without fibrosis, and hepatocellular carcinoma,...
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Novel therapeutic targets in primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is a chronic immune-mediated liver disease characterized by progressive cholestasis, biliary fibrosis and eventually...
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Cholesterol gallstone disease: focusing on the role of gallbladder
Gallstone disease (GSD) is one of the most common biliary tract diseases worldwide in which both genetic and environmental factors have roles in its...
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Bile acid mediated effects on gut integrity and performance of early-weaned piglets
BackgroundEarly weaning (EW) results in a transient period of impaired integrity of the intestinal mucosa that may be associated with reduced plasma...
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The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review
Background:Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities, such as diabetes....
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Vitamin D and energy homeostasis—of mice and men
The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D 3 , the active form of vitamin D, not...
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TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease affecting the intrahepatic and extrahepatic biliary tree leading to bile duct...
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Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery
Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities....
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Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
Aims/hypothesisTargeting the secretion of gut peptides such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) is a strategy under development...
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Bile acid receptors as targets for drug development
The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-coupled receptor TGR5 respond to bile acids by activating...
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Lipid-lowering Therapies, Glucose Control and Incident Diabetes: Evidence, Mechanisms and Clinical Implications
Lipid-lowering therapies constitute an essential part in the treatment and prevention of cardiovascular diseases and are consistently shown to reduce...
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Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy
Chronic diarrhoea induced by bile acids is common and the underlying mechanisms are linked to homeostatic regulation of hepatic bile acid synthesis...
