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Is intraoperative electrocorticography (ECoG) for long-term epilepsy-associated tumors (LEATs) more useful in children?—A Randomized Controlled Trial
ObjectivesThe utility of intraoperative electrocorticography (ECoG)-guided resective surgery for pediatric long-term epilepsy-associated tumors...
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Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study
BackgroundInsights into the burden, needs and treatment of migraine from internet-based surveys in diverse real-world migraine populations are...
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Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10–17-year follow-up study
PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve...
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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population
BackgroundLevetiracetam is an antiseizure medication used for several seizure types in adults and children aged 1 month and older; however, due to a...
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Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy
One third of patients with epilepsy will continue to have uncontrolled seizures despite treatment with antiseizure medications (ASMs). There is...
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Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy
IntroductionSelf-limited infantile epilepsy (SeLIE) is a benign epilepsy. Previous studies have shown that monotherapy with most antiseizure...
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Neonatal seizures—diagnostic options and treatment recommendations
Seizures in neonates should prompt rapid evaluation to verify the diagnosis, determine etiology, and initiate appropriate treatment. Neonatal seizure...
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Language impairments in seropositive and seronegative autoimmune encephalitis
Background and objectiveAutoimmune encephalitis (AE) is a rare neuroinflammatory disease affecting the central nervous system. To examine language...
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Acute Valproate-Induced Encephalopathy in Status Epilepticus: A Registry-Based Assessment
BackgroundValproate-induced encephalopathy (VIE) affects between 0.1% and 2.5% of patients under long-term epilepsy treatment. Its frequency and...
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the modulation of neuronal excitability, and a disruption of...
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Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a prevalence of 0.9% in the...
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Early identification of seizure freedom with medical treatment in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
BackgroundMesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is usually associated with a poor response to antiseizure medications....
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Anti-seizure medication is not associated with an increased risk to develop cancer in epilepsy patients
ObjectiveWhether anti-seizure medication (ASM) increases the risk for cancer has been debated for decades. While for some ASM, a carcinoma-promoting...
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Effects of stigma on the quality of life in patients with epilepsy
BackgroundThis study was aimed to evaluate the stigma and quality of life (QoL) in adult patients with epilepsy (PWEs) and explore the relationship...
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The effect of lacosamide monotherapy on sleep architecture in patients with epilepsy: a preliminary evidence
Lacosamide (LCM) is a third-generation antiseizure medication (ASM), and its effect on sleep architecture was supported by a few studies in patients...
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Distinguishing Benign Rashes From Severe Skin Reactions From Anti-Seizure Medications
Purpose of reviewThis review describes risk factors for severe skin reactions to antiseizure medications (ASMs), the usage of updated tests to...
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Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy
BackgroundEpileptic spasms are a devastating form of early infantile epileptic encephalopathy (EIEE) with various etiologies. Early diagnosis and a...
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Effectiveness and Tolerability of 12-Month Brivaracetam in the Real World: EXPERIENCE, an International Pooled Analysis of Individual Patient Records
Background and ObjectiveReal-world evidence studies of brivaracetam (BRV) have been restricted in scope, location, and patient numbers. The objective...
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Risk factors and outcome of hyperammonaemia in people with epilepsy
BackgroundHyperammonaemia is a recognised complication of antiseizure treatment but risk factors leading to individual patient susceptibility and...
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Channelopathies in epilepsy: an overview of clinical presentations, pathogenic mechanisms, and therapeutic insights
Pathogenic variants in genes encoding ion channels are causal for various pediatric and adult neurological conditions. In particular, several...
