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Flaxseed oil ameliorated high-fat-diet-induced bone loss in rats by promoting osteoblastic function in rat primary osteoblasts
Backgroundα-Linolenic acid (ALA) is a plant-derived omega-3 unsaturated fatty acid that is rich in flaxseed oil (FO). The effect of FO on bone health...
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Plasminogen activator inhibitor-1 is involved in glucocorticoid-induced decreases in angiogenesis during bone repair in mice
IntroductionGlucocorticoids delay fracture healing and induce osteoporosis. Angiogenesis plays an important role in bone repair after bone injury....
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Pathodynamics
Osteoporosis and osteoporosis-related fractures in the aging population are becoming a health care problem and a burden on health service resources...
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FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
The specific pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) is still not fully understood, and there is currently no...
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Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles
The cells of origin of neurogenic heterotopic ossifications (NHOs), which develop frequently in the periarticular muscles following spinal cord...
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Calcification and resorption of mouse Meckel’s cartilage analyzed by von Kossa and tartrate-resistant acid phosphatase histochemistry and scanning electron microscopy/energy-dispersive X-ray spectrometry
Meckel’s cartilage is essential for the normal development of the mandible. The fate of the intermediate portion of Meckel’s cartilage is unique as...
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Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies
Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells...
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Exogenous melatonin prevents type 1 diabetes mellitus–induced bone loss, probably by inhibiting senescence
SummaryExogenous melatonin inhibited the senescence of preosteoblast cells in type 1 diabetic (T1D) mice and those cultured in high glucose (HG) by...
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A prospective case–control study on the evaluation of oxidative stress in renal stone formers
Association of increased oxidative stress (OS) with the pathophysiology of renal stone formation has not been explored greatly in the field of...
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The clinical characteristics and prognosis of patients with SAPHO syndrome——a real-world cohort study
ObjectivesWe aimed to analyze the clinical characteristics and outcomes of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis...
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PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib
Skeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2) concentration in bone. Vertebral endplates undergo ossification...
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How does Hashimoto’s thyroiditis affect bone metabolism?
Bone marrow contains resident cellular components that are not only involved in bone maintenance but also regulate hematopoiesis and immune...
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A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation
PurposeEndochondral ossification, which involves transdifferentiation of chondrocytes into osteoblasts, is an important process involved in the...
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KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43
BackgroundOssification of ligamentum flavum (OLF) is a prevalent degenerative spinal disease, typically causing severe neurological dysfunction....
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Metabolic regulation of skeletal cell fate and function
Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxygen and nutrients....
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Epigenetic Regulators of Mesenchymal Stem/Stromal Cell Lineage Determination
Purpose of ReviewAlthough many signalling pathways have been discovered to be essential in mesenchymal stem/stromal (MSC) differentiation, it has...
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Dietary restriction plus exercise change gene expression of Cxcl12 abundant reticular cells in female mice
IntroductionLow energy availability due to excessive exercise lowers bone mass and impairs various physiological functions, including immunity and...
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A novel serological biomarker are associated with disease severity in patients with osteoarthritis
Background and aimApolipoprotein D (ApoD) is a 25–30 kDa glycoprotein, as a distinct component of the human plasma lipoprotein system. Its known...
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Secreted microRNAs in bone metastasis
Bone metastasis is a common complication in several solid cancers, including breast, prostate, and lung. In the bone microenvironment, metastatic...
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Amino Acid Metabolism in Bone Metastatic Disease
Purpose of ReviewBreast and prostate tumors frequently metastasize to the bone, but the underlying mechanisms for osteotropism remain elusive. An...
