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Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data
Genome-wide association studies (GWAS) of suicidal thoughts and behaviors support the existence of genetic contributions. Continuous measures of...
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Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan
BackgroundCluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies...
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Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications
BackgroundGenetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the...
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A genome-wide association study of the longitudinal course of executive functions
Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising...
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A genome-wide association study on adherence to low-carbohydrate diets in Japanese
Background/objectivesLow-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal...
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Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis
BackgroundTo study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared...
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Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P...
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Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins
BackgroundElevated fasting plasma glucose (FPG) levels can increase morbidity and mortality even when it is below the diagnostic threshold of type 2...
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Genome-wide DNA methylation analysis related to ALS patient progression and survival
BackgroundEpigenetics contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). We aimed to characterize the DNA methylation profiles...
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Genome wide association study identifies four loci for early onset schizophrenia
Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide...
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Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia
BackgroundOver 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were...
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Using “-omics” Data to Inform Genome-wide Association Studies (GWASs) in the Osteoporosis Field
Purpose of ReviewOsteoporosis constitutes a major societal health problem. Genome-wide association studies (GWASs) have identified over 1100 loci...
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Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis
SummaryIn this study, we integrated large-scale GWAS summary data and used the predicted transcriptome-wide association study method to discover...
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Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study
Aims/hypothesisWe investigated whether the impacts of childhood adiposity on adult-onset diabetes differ across proposed diabetes subtypes using a...
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Genome-wide investigation of lncRNAs revealed their tight association with gastric cancer
BackgroundGastric cancer (GC) is a significant health issue globally, ranking as the fifth most common cancer with over 10,000 new cases reported...
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Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation
Cognitive impairment is prevalent in blood or marrow transplantation (BMT) recipients, albeit with inter-individual variability. We conducted a...
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Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders
Identifying genetic contributors to cognitive impairments in psychosis-spectrum disorders can advance understanding of disease pathophysiology....
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ATAD3B and SKIL polymorphisms associated with antipsychotic-induced QTc interval change in patients with schizophrenia: a genome-wide association study
QTc interval prolongation is one of the most common antipsychotic-induced side effects which could lead to ventricular tachycardia or Torsade de...
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Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Triple negative breast cancer (TNBC) is defined as lacking the expressions of estrogen receptor (ER), progesterone receptor (PR), and human epidermal...
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A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
BackgroundSensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss...
