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The development, incidence and treatment trends of trochanteric fractures in Germany: a cohort study
BackgroundHip fractures are a major public health problem worldwide and can lead to disability, increased mortality, and reduced quality of life. We...
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Trisomy 18—when the diagnosis is compatible with life
Trisomy 18 is an autosomal chromosomal disorder characterized by the presence of an extra 18 chromosome. In the last decades, and as novel...
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Advanced Life Support Update
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be...
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Neurocritical care physicians’ doubt about whether to withdraw life-sustaining treatment the first days after devastating brain injury: an interview study
BackgroundMultilevel uncertainty exists in the treatment of devastating brain injury and variation in end-of-life decision-making is a concern....
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Treatment of multisystem inflammatory syndrome in children
BackgroundMultisystem inflammatory syndrome in children (MIS-C), a relatively uncommon but severe pediatric complication, is associated with...
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Therapeutic Options for Patients with Refractory Status Epilepticus in Palliative Settings or with a Limitation of Life-Sustaining Therapies: A Systematic Review
BackgroundRefractory status epilepticus (RSE) represents a serious medical condition requiring early and targeted therapy. Given the increasing...
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Updating our understanding of health-related quality of life issues in children with cancer: a systematic review of patient-reported outcome measures and qualitative studies
BackgroundHealth-related quality of life (HRQOL) is a key concept in pediatric oncology. This systematic review aims to update the conceptual HRQOL...
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The “black box” of treatment: Patients’ perspective on what works in opioid maintenance treatment for opioid dependence
BackgroundA lack of conceptual modeling of how the components of opioid maintenance treatment (OMT) for opioid dependence (OD) work causes it to...
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Quality indicators of palliative care for cardiovascular intensive care
Healthcare providers working for cardiovascular intensive care often face challenges and they play an essential role in palliative care and...
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Cultural impediments to frank communication regarding end-of-life care between older nursing home residents and their family members in Taiwan: a qualitative study
BackgroundWhen older nursing home residents and their families are faced with end-of-life care decisions in Taiwan, they make them in the context of...
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Bereaved parents’ perspectives on their child’s end-of-life care: connecting a self-report questionnaire and interview data from the nationwide Paediatric End-of-LIfe CAre Needs in Switzerland (PELICAN) study
BackgroundPaediatric Palliative Care (PPC) focuses on ensuring the best possible quality of life for the child and his/her family by extending beyond...
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Geriatric polytrauma patients should not be excluded from aggressive injury treatment based on age alone
PurposeAge in severely injured patients has been increasing for decades. Older age is associated with increasing mortality. However, morbidity and...
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Could palliative sedation be seen as unnamed euthanasia?: a survey among healthcare professionals in oncology
BackgroundIn 2016 a French law created a new right for end-of-life patients: deep and continuous sedation maintained until death, with...
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A phase I clinical trial of sonodynamic therapy combined with temozolomide in the treatment of recurrent glioblastoma
PurposeThe prognosis of recurrent glioblastoma (rGBM) is poor, and there is currently no effective treatment strategy. Sonodynamic therapy (SDT) is a...
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Equity in Clinical Care and Research Involving Persons with Disorders of Consciousness
People with disorders of consciousness (DoC) are characteristically unable to synchronously participate in decision-making about clinical care or...
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Baseline health-related quality of life predicts falls: a secondary analysis of a randomized controlled trial
PurposeAmong older adults, health-related quality of life (HRQoL) and falls are associated. Generic patient-reported outcomes measures (PROMs) assess...
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Palliative sedation in amyotrophic lateral sclerosis: results of a nationwide survey among neurologists and palliative care practitioners in Germany
BackgroundPalliative sedation has become widely accepted as a method to alleviate refractory symptoms in terminally ill patients. Controversies...
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Clinical Characteristics and Outcomes of Children with Acute Catastrophic Brain Injury: A 13-Year Retrospective Cohort Study
BackgroundThe purpose of this study was to describe and analyze clinical characteristics and outcomes in children with acute catastrophic brain...
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A beginner’s view of end of life care on German intensive care units
BackgroundLittle is known about importance and implementation of end-of-life care (EOLC) in German intensive care units (ICU). This survey analyses...
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Beliefs of physician directors on the management of devastating brain injuries at the Canadian emergency department and intensive care unit interface: a national site-level survey
PurposeInsufficient evidence-based recommendations to guide care for patients with devastating brain injuries (DBIs) leave patients vulnerable to...