Search
Search Results
-
-
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA
Major depressive disorder (MDD) is characterized by diverse debilitating symptoms that include loss of motivation and anhedonia. If multiple...
-
[18F]-FDG uptake in brain slices prepared from an aged mouse model of Alzheimer’s disease using a dynamic autoradiography technique
Objective2-[ 18 F]fluoro-2-deoxy- d -glucose positron emission tomography ([ 18 F]-FDG-PET) is a imaging modality that has been used to measure of glucose...
-
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
Aims/hypothesisChronic hyperglycaemia and recurrent hypoglycaemia are independently associated with accelerated cognitive decline in type 1 diabetes....
-
Successful engraftment of bladder organoids in de-epithelialized mouse colon
PurposeTo engraft bladder organoids (BO) on de-epithelialized mouse colon using an epithelial replacement technique.
MethodsBO cultured using...
-
Differences in renal cortex transcriptional profiling of wild-type and novel type B cystinuria model rats
Cystinuria is a genetic disorder of cystine transport that accounts for 1–2% of all cases of renal lithiasis. It is characterized by hyperexcretion...
-
Development of minimally invasive cancer immunotherapy using anti-disialoganglioside GD2 antibody-producing mesenchymal stem cells for a neuroblastoma mouse model
PurposeMouse IgG anti-disialoganglioside GD2 antibody-secreting mouse mesenchymal stem cells (anti-GD2-MSCs) were developed, and their anti-tumor...
-
An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome
We developed an IGFBP2-mimetic peptide fragment, JB2, and showed that it promotes basal synaptic structural and functional plasticity in cultured...
-
Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer
Although the role of isocitrate dehydrogenase (IDH) mutation in promoting cancer development has been well-characterized, the impact of wild-type IDH...
-
Therapeutic efficacy of a K5-specific phage and depolymerase against Klebsiella pneumoniae in a mouse model of infection
Klebsiella pneumoniae has become one of the most intractable gram-negative pathogens infecting humans and animals due to its severe antibiotic...
-
GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Aims/hypothesisDiabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic...
-
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth metacarpals. In the...
-
Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by mutations affecting paternal chromosome 15q11-q13, and characterized by...
-
Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review
Introduction and hypothesisMouse knockout (KO) models of pelvic organ prolapse (POP) have contributed mechanistic evidence for the role of connective...
-
Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype
Extensive evidence supports the role of the immune system in modulating brain function and behaviour. However, past studies have revealed striking...
-
Loss of the wild-type KRAS allele promotes pancreatic cancer progression through functional activation of YAP1
Human pancreatic ductal adenocarcinoma (PDAC) harboring one KRAS mutant allele often displays increasing genomic loss of the remaining wild-type (WT)...
-
The Eμ-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia
The presence of supernumerary chromosomes is the only abnormality shared by all patients diagnosed with high-hyperdiploid B cell acute lymphoblastic...
-
Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory
Delayed upregulation of the neuronal chloride extruder KCC2 underlies the progressive shift in GABA signaling polarity during development....
-
Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse
BackgroundAnthocyanins are a group of natural products widely found in plants. They have been found to alleviate the disorders of glucose metabolism...
-
iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer
BackgroundiMN013 (5-aza-2',2'-difluorodeoxycytidine), a DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor, and its prodrug...
