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Iptacopan: First Approval
Iptacopan (FABHALTA ® ) is an oral complement Factor B inhibitor developed by Novartis Pharmaceuticals for the treatment of complement-mediated...
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Is the commercial determinants conversation confined to the health sciences? Potentially, and that’s a problem
The commercial determinants of health (CDoH) are attracting increased interest and are of great importance when discussing how trade affects health....
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The Influence of Housing Status and Food Insecurity on a Behavioral HIV/STI Prevention Intervention for Black Women under Community Supervision in New York City: A Moderation Analysis
Black women in community supervision programs (CSPs) are disproportionately affected by HIV and other sexually transmitted infections (STIs). A...
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Imaging features of COVID-19-associated secondary sclerosing cholangitis on magnetic resonance cholangiopancreatography: a retrospective analysis
BackgroundDespite emerging reports of secondary sclerosing cholangitis (SSC) in critically ill COVID-19 patients little is known about its imaging...
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Biliary atresia: insights into mechanisms using a toxic model of the disease including Wnt and Hippo signaling pathways and microtubules
BackgroundMechanisms underlying bile duct injury in biliary atresia (BA) remain unclear and mechanisms of bile duct repair are unknown. This study...
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PIK3CD correlates with prognosis, epithelial–mesenchymal transition and tumor immune infiltration in breast carcinoma
BackgroundBreast carcinoma (BRCA) is one of the most common, fatal, and aggressive cancers, with increasing morbidity that has a major impact on...
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A case of pancreatic ductal adenocarcinoma concomitant with IgG4-related disease in the pancreas and the stomach
A 75-year-old Japanese woman visited a hospital with a stomachache. The patient was diagnosed with localized mild acute pancreatitis. Blood tests...
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Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention
BackgroundExercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular...
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Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most...
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Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets
Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) show a substantial...
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COVID-19-related global health governance and population health priorities for health equity in G20 countries: a sco** review
Since the declaration of the COVID-19 pandemic, the promotion of health equity including the health of various population sub-groups has been...
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Thrombectomy of the Profunda Femoral Vein in Iliofemoral Deep Venous Thrombosis Using an Antegrade Popliteal Approach
PurposeResidual or undertreated inflow disease is a major cause of stent occlusion following endovascular thrombectomy for iliofemoral deep venous...
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Preventing Youth Suicide: Potential “Crossover Effects” of Existing School-Based Programs
Notable increases in youth mental health problems combined with strains on the already stretched mental health workforce raise concerns that there...
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Bayesian network modelling to identify on-ramps to childhood obesity
BackgroundWhen tackling complex public health challenges such as childhood obesity, interventions focused on immediate causes, such as poor diet and...
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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and...
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Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
Despite considerable research efforts, it is still not clear which mechanisms underlie neuronal cell death in neurodegenerative diseases. During the...
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Clinical value and molecular mechanism of AQGPs in different tumors
Aquaglyceroporins (AQGPs), including AQP3, AQP7, AQP9, and AQP10, are transmembrane channels that allow small solutes across biological membranes,...
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Physical exercise mediates a cortical FMRP–mTOR pathway to improve resilience against chronic stress in adolescent mice
Aerobic exercise effectively relieves anxiety disorders via modulating neurogenesis and neural activity. The molecular mechanism of exercise-mediated...
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LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization
ObjectiveYAP1 plays a dual role as an oncogene and tumor suppressor gene in several tumors; differentiating between these roles may depend on the...
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Controlling the obesity pandemic: Geoffrey Rose revisited
The ongoing obesity pandemic threatens the health of hundreds of millions globally. However, to date, no country has had much success in limiting its...
