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“Don’t Think Twice, It’s All Right”: Using Additional Data to Reduce Uncertainty Regarding Oncologic Drugs Provided Through Managed Access Agreements in England
ObjectivesThe Cancer Drugs Fund (CDF) in England uses managed access agreements to facilitate additional data collection to address uncertainties...
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Uncertainty and probability in neonatal end-of-life decision-making: analysing real-time conversations between healthcare professionals and families of critically ill newborns
BackgroundA significant number of critically ill neonates face potentially adverse prognoses and outcomes, with some of them fulfilling the criteria...
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A narrative review of the literature on illness uncertainty in hypermobile ehlers-danlos syndrome: implications for research and clinical practice
BackgroundHypermobile Ehlers-Danlos syndrome (hEDS) is characterized by joint and skin laxity, and often accompanied by chronic pain, dysautonomia,...
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Cancer patients attending treatment during COVID-19: intolerance of uncertainty and psychological distress
PurposeThe COVID-19 pandemic presents specific challenges for cancer patients attending oncology treatment. Using a mixed-methods design (convergent...
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Design of a new Z-test for the uncertainty of Covid-19 events under Neutrosophic statistics
BackgroundThe existing Z-test for uncertainty events does not give information about the measure of indeterminacy/uncertainty associated with the...
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COVID-19 Uncertainty and Avoidance in Anxiety Related Disorders
Evidence-based practice inherently involves critical thinking and flexibility to deliver these treatments in an efficacious yet tailored manner....
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Women´s experiences of preeclampsia as a condition of uncertainty: a qualitative study
BackgroundPreeclampsia is a severe condition that annually affects about 3–8% of pregnancies worldwide. Preeclampsia is thereby one of the most...
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Bayesian additional evidence for decision making under small sample uncertainty
BackgroundStatistical inference based on small datasets, commonly found in precision oncology, is subject to low power and high uncertainty. In these...
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Application of a revised model for co** with advanced cancer to qualitatively explore lung cancer survivors’ experiences of ongoing physical effects, novel treatments, uncertainty, and co**
PurposeLung cancer remains underrepresented in cancer survivorship research. This study aimed to understand survivors’ physical/psychological...
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A neural and behavioral trade-off between value and uncertainty underlies exploratory decisions in normative anxiety
Exploration reduces uncertainty about the environment and improves the quality of future decisions, but at the cost of provisional uncertain and...
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Economic uncertainty and suicide in the United States
Previous studies have found an association between recessions and increased rates of suicide. In the present study we widened the focus to examine...
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Towards targeted ultrasound-guided prostate biopsy by incorporating model and label uncertainty in cancer detection
PurposeSystematic prostate biopsy is widely used for cancer diagnosis. The procedure is blind to underlying prostate tissue micro-structure; hence,...
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The relationship between anticipatory grief and illness uncertainty among Chinese family caregivers of patients with advanced lung cancer: a cross-sectional study
BackgroundAnticipatory grief has been shown to be highly prevalent among family caregivers of patients with advanced illness. Qualitative study...
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Statistical uncertainty quantification to augment clinical decision support: a first implementation in sleep medicine
Machine learning has the potential to change the practice of medicine, particularly in areas that require pattern recognition (e.g. radiology)....
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Detecting failure modes in image reconstructions with interval neural network uncertainty
PurposeThe quantitative detection of failure modes is important for making deep neural networks reliable and usable at scale. We consider three...
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Uncertainty and the unmet informational needs of patients with cancer of unknown primary (CUP): a cross-sectional multi-site study
ObjectiveThis study aimed to determine the healthcare experiences, quality of life, and psychosocial needs of patients with cancer of unknown primary...
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Validation of the intolerance of uncertainty scale as a screening tool for perinatal anxiety
BackgroundTo date, there is a significant lack of research validating clinical tools for early and accurate detection of anxiety disorders in...
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Prescriber Uncertainty as Opportunity to Improve Care of Type 2 Diabetes with Chronic Kidney Disease: Mixed Methods Study
BackgroundOver 5 million patients in the United States have type 2 diabetes mellitus (T2D) with chronic kidney disease (CKD); antidiabetic drug...
