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Exosome-mediated delivery of super-repressor IκBα alleviates inflammation and joint damages in rheumatoid arthritis
BackgroundThis study aims to investigate the potential anti-inflammatory effects of exosomes engineered to carry super-repressor IκB (Exo-srIκB), an...
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Bleeding complications in patients on warfarin undergoing joint injection/aspiration: systematic review and meta-analysis
Steroid injections in joints are commonly administered for the management of inflammatory or degenerative conditions. There is substantial...
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Characterization of periprosthetic environment microbiome in patients after total joint arthroplasty and its potential correlation with inflammation
AimsPeriprosthetic joint infection (PJI) is one of the most serious complications after total joint arthroplasty (TJA) but the characterization of...
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Parathyroid hormone (1–34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats
PurposeFacet joint degeneration (FJD) is a major cause of low back pain. Parathyroid hormone (PTH) (1–34) is commonly used to treat osteoporosis....
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The role of advanced metal artifact reduction MRI in the diagnosis of periprosthetic joint infection
Identification and diagnosis of periprosthetic joint infection (PJI) are challenging, requiring a multi-disciplinary approach involving clinical...
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Maintenance of the joint line and posterior condylar offset are the most notable variables for successful outcomes of revision total knee arthroplasty
IntroductionControversy regarding which variables should be prioritized for better outcomes in revision total knee arthroplasty (RTKA) exists. This...
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Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms
Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient...
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Deletion of Bmal1 in aggrecan-expressing cells leads to mouse temporomandibular joint osteoarthritis
IntroductionArticular cartilage is the major affected tissue during the development of osteoarthritis (OA) in temporomandibular joint (TMJ). The core...
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Develo** standards for MRI evaluation of joints in children with juvenile idiopathic arthritis utilizing the temporomandibular joint as a model
The treatment of a patient with juvenile idiopathic arthritis (JIA) is best monitored with standardized and validated tools to measure joint changes...
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Ferroptosis: a new target for iron overload-induced hemophilic arthropathy synovitis
Iron deposition is closely related to develo** haemophilic arthropathy (HA). Studying the relationship between ferroptosis signal expression and...
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The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
ObjectiveIn gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and the maturation of...
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Quantitative MRI assessment of joint effusion using T2-relaxometry at 3 Tesla: a feasibility and reproducibility study
ObjectiveT2-relaxometry could differentiate between physiological and haemorrhagic joint effusion (≥ 5% blood) in vitro. Are quantitative...
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Quality of life and clinical assessment of joint health in children with hemophilic arthropathy
BackgroundHemophilic arthropathy results in pain, deformity, and disability with severe impairments, activity limitation, and thus productivity loss....
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Prehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial
BackgroundApproximately, 8% of community-based adults aged ≥ 50 years in England are frail. Frailty has been found to be associated with poorer...
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Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up
BackgroundThe aim of this study was to compare pain-scores in three targeted treatment-strategies in JIA-patients and to identify characteristics...
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A review of current practices in periprosthetic joint infection debridement and revision arthroplasty
BackgroundPeriprosthetic joint infection remains a significant challenge for arthroplasty surgeons globally. Over the last few decades, there has...
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Measurement properties of cervical joint position error in people with and without neck pain: a systematic review and narrative synthesis
IntroductionProprioception can be impaired in people with neck pain. The cervical joint position sense test, which measures joint position error...
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Promising applications of D-amino acids in periprosthetic joint infection
Due to the rise in our aging population, a disproportionate demand for total joint arthroplasty (TJA) in the elderly is forecast. Periprosthetic...
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Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway
BackgroundOsteoarthritis (OA) is a joint disease characterized by inflammation and progressive cartilage degradation. Chondrocyte apoptosis is the...
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Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis? Data from the IMI-APPROACH cohort
ObjectiveTo determine the association between joint structure and gait in patients with knee osteoarthritis (OA).
MethodsIMI-APPROACH recruited 297...
