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A novel diabetes typology: towards precision diabetology from pathogenesis to treatment
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies and some insufficiently defined clinical features, does...
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Responding to and Driving Change in Rheumatology: Report from the 12th International Immunology Summit 2021
The coronavirus disease 2019 (COVID-19) pandemic has accelerated changes to rheumatology daily clinical practice. The main goal of the 12th...
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Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial
BackgroundObesity increases the risk of type 2 diabetes, heart disease, stroke, mobility problems and some cancers, and its prevalence is rising. Men...
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A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease
PurposeGiven the substantial risk of treatment failure in inflammatory bowel disease (IBD), adjuvant therapies may play a role in disease management....
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Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare
Precision Medicine implies a deep understanding of inter-individual differences in health and disease that are due to genetic and environmental...
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Geographic and sociodemographic access to systemic anticancer therapies for secondary breast cancer: a systematic review
BackgroundThe review aimed to investigate geographic and sociodemographic factors associated with receipt of systemic anticancer therapies (SACT) for...
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Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial
BackgroundOsteoarthritis (OA) has long been considered as a degenerative disease of cartilage tissue resulting from bodily wear and tear. However,...
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The D*Phase-study: study protocol for a pragmatic two-phased, randomised controlled (non-inferiority) trial that addresses treatment non-response and compares cognitive behavioural therapy and short-term psychodynamic supportive psychotherapy for major depression
BackgroundSeveral evidence-based psychotherapeutic treatment options are available for depression, but the treatment results could be improved. The...
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based randomised controlled trial
BackgroundCombining short-acting nicotine replacement therapy with varenicline increases smoking cessation rates compared with varenicline alone, but...
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Prevalence of chronic pelvic pain and associated factors among indigenous women of reproductive age in Ecuador
BackgroundChronic pelvic pain is a common disease that affects approximately 4% of women of reproductive age in developed countries. This number is...
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Exploring Antipsychotic Use for Delirium Management in Adults in Hospital, Sub-Acute Rehabilitation and Aged Care Settings: A Systematic Literature Review
BackgroundInternational guidelines discourage antipsychotic use for delirium; however, concerns persist about their continued use in clinical...
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The utility of a genetic kidney disease clinic employing a broad range of genomic testing platforms: experience of the Irish Kidney Gene Project
Background and aimsGenetic testing presents a unique opportunity for diagnosis and management of genetic kidney diseases (GKD). Here, we describe the...
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Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study
BackgroundWhile the Glasgow coma scale (GCS) is one of the strongest outcome predictors, the current classification of traumatic brain injury (TBI)...
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Perspectives of diabetic retinopathy—challenges and opportunities
Diabetic retinopathy (DR) may lead to vision-threatening complications in people living with diabetes mellitus. Decades of research have contributed...
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Reviewing Treatment Options for Advanced Renal Cell Carcinoma: Is There Still a Place for Tyrosine Kinase Inhibitor (TKI) Monotherapy?
Renal cell carcinoma (RCC) comprises a highly heterogeneous group of kidney tumours built upon distinct genetic- and epigenetic-driven mechanisms and...
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Return on investment in science: twenty years of European Commission funded research in Alzheimer’s dementia, breast cancer and prostate cancer
Alzheimer’s disease (AD), breast cancer (BC) and prostate cancer (PC) continue to be high in the research and innovation agenda of the European...
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The PRolaCT studies — a study protocol for a combined randomised clinical trial and observational cohort study design in prolactinoma
BackgroundFirst-line treatment for prolactinomas is a medical treatment with dopamine agonists (DAs), which effectively control hyperprolactinaemia...
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Increasing uptake to a lung cancer screening programme: building with communities through co-design
BackgroundLung cancer is the most common cause of cancer death in the UK. Low-dose computed tomography (LDCT) screening has been shown to identify...
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Informational needs and predictors of Jordanian breast and colorectal cancer survivors: a national cross-sectional study
PurposeTo investigate the informational gap and predictors of information-seeking behaviour amongst survivors to inform survivorship planning and...
