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The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma: a study protocol
BackgroundAsthma is a common disease characterized by chronic inflammation of the lower airways, bronchial hyperactivity, and (reversible) airway...
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Prediction of mortality in acute pulmonary embolism in cancer-associated thrombosis (MAUPE-C): derivation and validation of a multivariable model
Optimal risk stratification of patients with cancer and pulmonary embolism (PE) remains unclear. We constructed a clinical prediction rule (CPR)...
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RegEMR: a natural language processing system to automatically identify premature ovarian decline from Chinese electronic medical records
BackgroundThe ovarian reserve is a reservoir for reproductive potential. In clinical practice, early detection and treatment of premature ovarian...
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Natural Language Processing Algorithm Used for Staging Pulmonary Oncology from Free-Text Radiological Reports: “Including PET-CT and Validation Towards Clinical Use”
Natural language processing (NLP) can be used to process and structure free text, such as (free text) radiological reports. In radiology, it is...
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Pharmacokinetic studies, molecular docking, and molecular dynamics simulations of phytochemicals from Morus alba: a multi receptor approach for potential therapeutic agents in colorectal cancer
This study explores the therapeutic potential of phytochemicals derived from Morus alba for colorectal cancer (CRC) treatment. Colorectal cancer is a...
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Primary Headache Associated with Sexual Activity: A Review of the Literature
Purpose of ReviewThis review summarizes the evolution in diagnosis, evaluation, and treatment of primary headache associated with sexual activity...
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Blue Nail Discoloration: Literature Review and Diagnostic Algorithms
Blue nail discoloration is a distinctive clinical presentation, and diagnosis is challenging given the broad differential diagnosis. A comprehensive...
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Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L
Colorectal cancer (CRC) has the second highest incidence and fatality rates of any malignancy, at 10.2 and 9.2%, respectively. Plants and...
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Revisiting the effects of state earned income tax credits on infant health: a quasi-experimental study using contiguous border counties approach
BackgroundTo examine the effects of refundable state earned income tax credits (EITC) on infant health.
MethodsWe use the restricted-access U.S....
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Strategies to safely rule out pulmonary embolism in COVID-19 outpatients: a multicenter retrospective study
ObjectivesThe objective was to define a safe strategy to exclude pulmonary embolism (PE) in COVID-19 outpatients, without performing CT pulmonary...
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Industry Perspective on Artificial Intelligence/Machine Learning in Pharmacovigilance
TransCelerate reports on the results of 2019, 2020, and 2021 member company (MC) surveys on the use of intelligent automation in pharmacovigilance...
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Effectiveness of automated alerting system compared to usual care for the management of sepsis
There is a large body of evidence showing that delayed initiation of sepsis bundle is associated with adverse clinical outcomes in patients with...
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A Hierarchical Bayesian Latent Class Model for the Diagnostic Performance of Mini-Mental State Examination and Montreal Cognitive Assessment in Screening Mild Cognitive Impairment Due to Alzheimer’s Disease
BackgroundThe Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are low costing and noninvasive neuropsychological tests...
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EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD): Executive Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is defined as...
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Sex-related differences in visuomotor skill recovery following concussion in working-aged adults
BackgroundThe ability to perform visually-guided motor tasks requires the transformation of visual information into programmed motor outputs. When...
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Accurate classification of carotid endarterectomy indication using physician claims and hospital discharge data
Background and purposeStudies of carotid endarterectomy (CEA) require stratification by symptomatic vs asymptomatic status because of marked...
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Artificial intelligence-driven virtual rehabilitation for people living in the community: A sco** review
Virtual Rehabilitation (VRehab) is a promising approach to improving the physical and mental functioning of patients living in the community. The use...
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The role of shear wave elastography in differentiation between benign and malignant portal vein thrombosis in hepatocellular carcinoma
BackgroundHepatocellular carcinomas (HCC) most commonly complicate liver cirrhosis and it may coexist with malignant portal vein invasion (PVI) that...
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Development and application of Chinese medical ontology for diabetes mellitus
ObjectiveTo develop a Chinese Diabetes Mellitus Ontology (CDMO) and explore methods for constructing high-quality Chinese biomedical ontologies.
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Stratified Patient Profiling for Vedolizumab Effectiveness in Crohn’s Disease: Identifying Optimal Subgroups for Enhanced Treatment Response in the EVOLVE Study
IntroductionThis analysis evaluated the relative performance of vedolizumab and anti-tumor necrosis factor alpha (anti-TNFα) agents in subpopulations...