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Chronic Primary Pain of the Spine: an Integrative Perspective Part 1
The aim of this study is to conduct a narrative review of the literature emphasizing current models of non-specific low back and neck pain with an...
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Remote Electrical Neuromodulation for the Acute Treatment of Migraine in Patients with Chronic Migraine: An Open-Label Pilot Study
IntroductionRemote electrical neuromodulation (REN) is a novel acute treatment of migraine. Upper arm peripheral nerves are stimulated to induce...
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Genetic pain loss disorders
Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory neuropathies and, if autonomic nerves are involved, hereditary...
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Involvement between social defeat stress and pain-related behavior in a rat lumbar disk herniation model
IntroductionPsychological and social factors are involved in the disability and chronicity of pain. Our study aim was to investigate whether social...
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Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research
Neuropathic pain is a disease of the somatosensory system that is characterized by tingling, burning, and/or shooting pain. Medication is often the...
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Chronic Pain Following Cosmetic Breast Surgery: A Comprehensive Review
IntroductionCosmetic breast surgery is commonly performed in the United States; 520,000 procedures of the total 1.8 million cosmetic surgical...
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GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABAA-α4β1δ subunits in periaqueductal gray in female rats
BackgroundG-protein coupled estrogen receptor 30 (GPR30) was proved the specific estrogen receptor relating to mechanical hyperalgesia. Studies have...
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Lasmiditan mechanism of action – review of a selective 5-HT1F agonist
Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this...
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Hypothesis paper: electroacupuncture targeting the gut–brain axis to modulate neurocognitive determinants of eating behavior—toward a proof of concept in the obese minipig model
Acupuncture has thousands of years of history and perspective for the treatment of many health problems and disorders. Beneficial effects of...
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Descending Control Mechanisms and Chronic Pain
Purpose of ReviewThe goal of the review was to highlight recent advances in our understanding of descending pain-modulating systems and how these...
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Pathology of pain and its implications for therapeutic interventions
Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is...
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Zona incerta as a therapeutic target in Parkinson’s disease
The zona incerta has recently become an important target for deep-brain stimulation (DBS) in Parkinson’s disease (PD). The present review summarizes...
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Cannabis Use as a Risk Factor for Takotsubo (Stress) Cardiomyopathy: Exploring the Evidence from Brain-Heart Link
Purpose of ReviewRecently, an association between cannabis use and Takotsubo (stress) cardiomyopathy (TTC) has been shown. With the current trend of...
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The Ascending Reticular Activating System
Discovery of the ascending reticular activating system (ARAS) can be attributed to work done in research neuroscientist Horace Magoun’s laboratory....
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The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies
Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an increasing public health threat in the United States and...
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Tension-type headache
Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is characterized by recurrent headaches of mild to moderate...
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Central Nervous System Changes in Pelvic Inflammation/Pain Patients
Purpose of ReviewCentralized pain syndromes (CPS), including chronic pelvic pain (CPP) syndrome, are significant public health problems with...
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Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain
The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests...
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Neuroanatomical circuitry between kidney and rostral elements of brain: a virally mediated transsynaptic tracing study in mice
The identity of higher-order neurons and circuits playing an associative role to control renal function is not well understood. We identified...