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Evaluation of reporting quality of cohort studies using real-world data based on RECORD: systematic review
ObjectiveReal-world data (RWD) and real-world evidence (RWE) have been paid more and more attention in recent years. We aimed to evaluate the...
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Real-world data for precision public health of noncommunicable diseases: a sco** review
BackgroundGlobal public health action to address noncommunicable diseases (NCDs) requires new approaches. NCDs are primarily prevented and managed in...
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Weight loss response in patients with obesity treated with injectable semaglutide in a real-world setting
BackgroundObesity is defined as excess adipose tissue causing a deterioration in health, but diagnosing the causes and deciding on treatment can be...
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Treatment-Resistant Depression in Real-World Clinical Practice: A Systematic Literature Review of Data from 2012 to 2022
ObjectiveReal-world evidence in treatment-resistant depression (TRD; commonly defined as non-response to ≥ 2 consecutive treatments at adequate...
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Real-World Study of Adjuvant Biosimilar Trastuzumab-dkst for HER2-Positive Breast Cancer Treatment in a Brazilian Population
IntroductionBiological monoclonal antibodies play a pivotal role in cancer treatment, with biosimilars significantly enhancing their accessibility....
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Non-prescribing of clozapine for outpatients with schizophrenia in real-world settings: The clinicians’ perspectives
Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians...
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Verknüpfung von randomisierten kontrollierten Studien und Real World Data
BackgroundRandomized controlled trials (RCTs) are the gold standard for evaluating interventions. However, they are often considered to be difficult...
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Effectiveness of romosozumab in patients with osteoporosis at high fracture risk: a Japanese real-world study
IntroductionTo describe the real-world use of romosozumab in Japan, we conducted a chart review of > 1000 Japanese patients with osteoporosis (OP) at...
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Real-world use of multigene signatures in early breast cancer: differences to clinical trials
PurposeIn Italy, Lombardy was the first region to reimburse multigene assays (MGAs) for patients otherwise candidates for chemotherapy. This is a...
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Follow-up of vascular-targeted photodynamic therapy in a real-world setting
PurposeVascular-targeted photodynamic therapy (VTP) is an approved treatment option for unilateral low-risk prostate cancer (PCa).
Methods ...
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Adverse events of nivolumab plus ipilimumab versus nivolumab plus cabozantinib: a real-world pharmacovigilance study
BackgroundNo head-to-head clinical trials have compared the differences in adverse events (AEs) between nivolumab plus ipilimumab (NIVO-IPI) and...
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Panretinal photocoagulation plus intravitreal conbercept for diabetic retinopathy in real world: a retrospective study
BackgroundTo evaluate outcomes of panretinal photocoagulation (PRP) plus intravitreal conbercept (IVC) for diabetic retinopathy (DR) in real world...
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Decision Making About Disease-Modifying Treatments for Relapsing-Remitting Multiple Sclerosis: Stated Preferences and Real-World Choices
BackgroundPeople with relapsing-remitting multiple sclerosis can benefit from disease-modifying treatments (DMTs). Several DMTs are available that...
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Alzheimer’s Disease Linkage to Real-World Evidence (AD-LINE) Study: Linking Claims Data to Phase 3 GRADUATE Study of Gantenerumab
BackgroundLinking data from clinical trials and real-world claims may improve the robustness of trial data and provide information on the health,...
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Effectiveness of secukinumab in patients with psoriasis and psoriatic arthritis in a Saudi real-world setting
IntroductionPsoriasis (PsO) is an immune-mediated chronic inflammatory disease that results in severe outcomes that impact the patient’s quality of...
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Real-world performance of indobufen versus aspirin after percutaneous coronary intervention: insights from the ASPIRATION registry
BackgroundIndobufen is widely used in patients with aspirin intolerance in East Asia. The OPTION trial launched by our cardiac center examined the...
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Curation of myeloma observational study MALIMAR using XNAT: solving the challenges posed by real-world data
ObjectivesMAchine Learning In MyelomA Response (MALIMAR) is an observational clinical study combining “real-world” and clinical trial data, both...
