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Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals
Epidermal growth factor receptors (EGFR, HER2, HER3) activate signal transduction pathways involved in cancer proliferation, apoptosis,...
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Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging
Immune responses wane during aging, posing challenges to the potential effectiveness of cancer immunotherapies. We previously demonstrated that in...
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Exploring the anti-diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays
BackgroundPlant-derived compounds have been used clinically to treat type 2 diabetes for many years as they also exert additional beneficial effects...
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Targeting metabolic disorders by natural products
The most prevalent metabolic disorders are diabetes mellitus, obesity, dyslipidemia, osteoporosis and metabolic syndrome, which are developed when...
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Genomic Analysis of Pterostilbene Predicts Its Antiproliferative Effects Against Pancreatic Cancer In Vitro and In Vivo
BackgroundTo investigate the inhibitory role of pterostilbene in pancreatic cancer, we conducted a genomic analysis of pterostilbene-treated...
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Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells
BackgroundGenistein (Gen) exhibits anti-mutagenic and anti-metastatic activities in hepatoma cell lines. Gen has suppressive effects on tumor growth...
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Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
PurposeResveratrol (3,5,4′-trihydroxy- trans -stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits, including...
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Gene-Diet Interactions on Colorectal Cancer Risk
There has been increasing interest lately in understanding how natural dietary antioxidants affect chemoprevention, and recently, there has been a...
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Pterostilbene Inhibits Pancreatic Cancer In Vitro
IntroductionStilbenes are phenolic compounds present in grapes and blueberries. Resveratrol, a naturally occurring compound present in grapes, has...
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Resveratrol and its impact on aging and thyroid function
Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to...
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Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
BackgroundAberrant regulation of glycogen synthase kinase-3β (GSK-3β) has been implicated in several human cancers; however, it has not been reported...
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Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon
BackgroundBlueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed...