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Changes in pituitary-adrenal activity affect the apomorphine- and cholecystokinin-8-induced changes in striatal dopamine release using microdialysis
The effects of apomorphine (0.05 mg/kg, i.p.) and cholecystokinin-8 (sulphated; CCK-8) were analyzed on the levels of dopamine and its metabolites...
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Quantification of the EEG Effect of Midazolam by Aperiodic Analysis in Volunteers
The effects of midazolam on the EEG were related to plasma midazolam concentrations in 8 healthy male volunteers in order to develop a...
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Pharmacokinetics of a new anticancer drug, navelbine, in patients
A study was designed to investigate the fate of navelbine (NVB) and its excretion routes in two cancer patients treated with tritiated NVB (30mg/m 2 )...
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Reversal of epidermal hyperproliferation in essential fatty acid deficient guinea pigs is accompanied by rapid generation of inositol triphosphate
This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in...
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Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites
Administration of high-dose uridine or cytidine (3500 mg/kg) resulted in severe hypothermia of 6–10°C in mice. This effect of uridine was observed in...
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Elevation of plasma levels of fluorinated pyrimidines by guanosine 5′-monophosphate
The plasma concentration of 5-fluorouracil (FUra) following the i.v. administration of FUra and guanosine 5′-monophosphate (GMP) or guanosine...
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The influence of gamma-irradiation upon the chemical and biological properties of insulin
Partially purified insulin preparations of bovine and porcine origin, were subjected to gamma-irradiation with doses ranging from 1.0 up to 25 kGy...
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Effects of pH on the stability of the indium-113m blood protein complex and the selective binding of indium-113m to transferrin
Indium-113m ( t 1/2 = 100min; gamma-emission of 393keV) in trace amounts was injected i.v. in rats. Blood was collected by heart puncture 15 min after...
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Diagnosis and treatment of gestational diabetes according to amniotic fluid insulin levels
In spite of dietary treatment, the infants of pregnant patients with abnormal glucose tolerance have hyperinsulinism and diabetogenic fetopathy in 10...
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Purification by high performance liquid chromatography of Clostridium perfringens type a enterotoxin prepared from high toxin producers selected by a toxin-antitoxin halo
High enterotoxin-producing substrains of Clostridium perfringens type A were selected reproducibly as colonies having toxin-antitoxin haloes on agar...
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The hormonal form of vitamin D in the pathophysiology and therapy of postmenopausal osteoporosis
Sixty-two women with symptomatic postmenopausal osteoporosis underwent longterm treatment with 1,25-dihydroxyvitamin D 3 . The following results were...
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Acute Secretory Diarrhoeas
Acute secretory diarrhoeas constitute a major source of mortality and morbidity worldwide. Our current understanding of the underlying mechanisms...
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Nutritional intervention among rural pre-school children—an evaluatory study
Nutritional intervention in the package form of medical care, supplementary feeding and education was offered to 82 severely malnourished children in...
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Comparative metabolism and excretion of adriamycin in man, monkey, and rat
Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and...
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Monitoring Serum Theophylline Levels
Recent definition of the pharmacodynamics and pharmacokinetics of theophylline have increased the safety and efficacy of the drug for acute...
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Some pitfalls in antisecretory drug trials
A standard anticholinergic drug was compared to a sustained-release preparation of the same agent. Two 6-hr. doses of glycopyrrolate were equivalent...