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Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study
BackgroundSepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to...
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Placenta-derived proteins across gestation in healthy pregnancies—a novel approach to assess placental function?
BackgroundPlacenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the...
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Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular...
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Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our...
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Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy
BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors...
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Just scratching the surface: novel treatment approaches for multiple myeloma targeting cell membrane proteins
A better understanding of the roles of the adaptive and innate immune systems in the oncogenesis of cancers including multiple myeloma (MM) has led...
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Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance
IntroductionThis study investigated changes in plasma microbial-derived extracellular vesicles (EVs) in patients with polycystic ovary syndrome and...
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Membrane Cholesterol Interactions with Proteins in Hypercholesterolemia-Induced Endothelial Dysfunction
Purpose of ReviewThe goal of this review is to highlight work identifying mechanisms driving hypercholesterolemia-mediated endothelial dysfunction....
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Possible-sarcopenic screening with disturbed plasma amino acid profile in the elderly
BackgroundThe mass and strength of skeletal muscle decline with age, leading to its progressive dysfunction. High-throughput metabolite profiling...
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Plasma proteome changes linked to late phase response after inhaled allergen challenge in asthmatics
BackgroundA subset of individuals with allergic asthma develops a late phase response (LPR) to inhaled allergens, which is characterized by a...
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Biochemical Characterization of a New 10% IVIG Preparation [IgG Next Generation (BT595)/Yimmugo®] Obtained from a Manufacturing Process Preserving IgA/IgM Potential of Human Plasma
Background and ObjectiveHuman plasma is used for the generation of several life-saving drugs and contains valuable antibodies from the immunoglobulin...
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Placental proteins with predicted roles in fetal development decrease in premature infants
BackgroundEmerging evidence from animal experiments indicate that factors secreted by the placenta are critical for normal fetal organ development....
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Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis
Background and purposeCerebral sinus venous thrombosis (CSVT) is a rare but life-threatening disease and its diagnosis remains challenging. Blood...
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Associations of plasma proteomics with type 2 diabetes and related traits: results from the longitudinal KORA S4/F4/FF4 Study
Aims/hypothesisThis study aimed to elucidate the aetiological role of plasma proteins in glucose metabolism and type 2 diabetes development.
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Idiopathic Lympho-Plasma Cellular Mucositis; A Diagnostic Predicament
The term “idiopathic lymphoplasmacellular mucositis” (ILPM) refers to a set of conditions marked by extensive lymphocyte and plasma cell infiltrates...
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Development of a blood proteins-based model for bronchopulmonary dysplasia prediction in premature infants
BackgroundBronchopulmonary dysplasia (BPD) is the most common chronic pulmonary disease in premature infants. Blood proteins may be early predictors...
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Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction
MicroRNA(miR)-143 and miR-145 are mainly expressed in vascular smooth muscle cells. However, the relationship between plasma miR-143 or miR-145...
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The effect of donation frequency on donor health in blood donors donating plasma by plasmapheresis: study protocol for a randomized controlled trial
BackgroundThe demand for plasma products is growing, necessitating an increase in plasma collection by plasmapheresis. While the 20th edition of the...
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Tau proteins in blood as biomarkers of Alzheimer’s disease and other proteinopathies
Alzheimer’s disease (AD), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular Aβ plaques...
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microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients
BackgroundAlthough previous studies show that microRNAs (miRNAs) can potentially be used as diagnostic markers for epilepsy, there are very few...
